桥本氏病血清促甲状腺激素升高对甲状腺组织癌变及中央区淋巴结转移影响-effect of serum thyrotropin increase in hashimotos disease on canceration of thyroid tissue and lymph node metastasis in central region.docxVIP

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桥本氏病血清促甲状腺激素升高对甲状腺组织癌变及中央区淋巴结转移影响-effect of serum thyrotropin increase in hashimotos disease on canceration of thyroid tissue and lymph node metastasis in central region.docx

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桥本氏病血清促甲状腺激素升高对甲状腺组织癌变及中央区淋巴结转移影响-effect of serum thyrotropin increase in hashimotos disease on canceration of thyroid tissue and lymph node metastasis in central region

目录中文摘要 ······························································································（ 1 ）英文摘要 ······························································································（ 2 ）论文题目 ······························································································（ 4 ）材料与方法 ···························································································（ 4 ）结果··································································································· （ 5 ）讨论··································································································· （ 7 ）结论··································································································· （ 1 0 ）参考文献 ···························································································· （ 10 ）文献综述 ···························································································· （ 14 ）参考文献 ···························································································· （ 21 ）缩略语表 ···························································································· （ 27 ）攻读学位期间发表文章情况 ···································································· （ 28 ）个人简历 ···························································································· （ 29 ）致谢···································································································（30）中文摘要目的探讨桥本氏病（Hashimoto’s thyroiditis、HT）血清促甲状腺素（TSH）水平升高对甲状腺组织癌变及中央区淋巴结转移影响。方法回顾性分析内蒙古医科大学附属医院 2009 年 1 月至 2013 年 12 月收治的病理证实为 HT 的 569 例完整临床资料，根据是否合并甲状腺乳头状癌（Papillary thyroid cancer、PTC）分为单纯 HT 和 HT 合并 PTC。HT 合并 PTC 组根据血清 TSH 水平分为 TSH 升高组(4.2mU/L，n=81)、TSH 正常组（0.2-4.2mU/L，n=182 例）。探讨年龄、性别、术前甲状腺功能（FT3、FT4、TSH、 TPOAb、TGAb）、多灶性、淋巴结转移情况等相关因素，分析术前 TSH 升高对 HT 甲状腺组织癌变及中央区淋巴结转移影响。结果 569 病理证实为 HT 的患者中 306 例为单纯 HT，263 例为 HT 合并 PTC。HT 合并 PTC 患者平均年龄（45.52±10.58）小于单纯 HT 组，P0.05。单纯 HT 组的女性人数占 95%，HT 合并 PTC 组的女性人数占 90%， P0.05。在单