瑞芬太尼与芬太尼对心脏瓣膜置换术患者ctni和h-fabp的影响-effects of remifentanil and fentanyl on ctni and h - fabp in patients undergoing cardiac valve replacement.docxVIP

瑞芬太尼与芬太尼对心脏瓣膜置换术患者ctni和h-fabp的影响-effects of remifentanil and fentanyl on ctni and h - fabp in patients undergoing cardiac valve replacement.docx

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瑞芬太尼与芬太尼对心脏瓣膜置换术患者ctni和h-fabp的影响-effects of remifentanil and fentanyl on ctni and h - fabp in patients undergoing cardiac valve replacement

结论体外循环瓣膜置换术中使用芬太尼和瑞芬太尼可获得稳定、相似的血流动力学效应;体外循环下心脏瓣膜置换手术可引起患者cTnI和H-FABP血清浓度增高,临床剂量下芬太尼和瑞芬太尼在心脏瓣膜置换手术中对cTnI和H-FABP的影响相似。关键词芬太尼;瑞芬太尼;心肌保护;cTnI;H-FABPEffectsofremifentanilandfentanylonthecTnIandH-FABPinpatientsundergoingheartvalvereplacementABSTRACTObjectiveToobservetheeffectofremifentanilandfentanylonthecTnIandH-FABPduringcardiopulmonarybypassinpatientswithvalvereplacementsurgery.Toevaluatethemyocardialeffectofclinicaldosesofremifentanilandfentanyl.Methods40caseswithsinglevalvereplacementsurgeryundercardiopulmonarybypasswereselectedandrandomlydividedintotwogroups.Fentanylgroup(Fgroup,n=20each)andremifentanilgroup(Rgroup,n=20each).Inductionofanesthesia:bothgroupswerefollowedbyintravenousinjectiontomidazolam0.05mg/kg,etomidate0.2mg/kgandcis-atracurium0.15mg/kg,theFgroupfentanyl10μg/kg,Rgroupremifentanil2μg/kg.?Maintanceofanesthesia:bothgroupsusingpropofol4~6mg?kg-1h-1maintainsedationbycontinuousinfusion,cis-atracuriumwasusedtomaintainmusclerelaxationbyintravenousinfusion.Atthefollowingtimepoint:beforetheskinincision,beforetheCPB,CPB,aftertheCPB,Fgroupusedfentanyl10~15μg/kgbyintravenousinjection,Rgroupusedremifentanil0.2~0.5μg?kg-1?min-1bycontinuousintravenousinfusionadjusttheinfusionrateaccordingtobloodpressureandheartrate.Themeanarterialpressure(MAP)andheartrate(HR)wererecordedinenteringtheroom,beforeintubation,1minafterintubation,incisionimmediately,beforeCPB,circulatoryarrest,theendofsurgery.Thecentralvenouspressure(CVP)wasrecordedinenteringtheroom,incisionimmediately,beforeCPB,circulatoryarrestandtheendofsurgery.Inbothgroupsrespectivelycollected5millilitersarterybloodfordeterminationofserumlevelsofcTnIandH-FABPactivitybeforeinductionofanesthesia(T0),beforeaorticcross-clamping(T1),1hourafteraorticopening(T2),3hoursafteraorticopening(T3),6hoursafteraorticopening(T4),12hoursafteraorticopening(T5),24hoursafteraorticopening(T6).Results①Cardiopulmonarybypasstime,operationtime,doseofpropofolandothernarcoticdrugs,MAP,HRandCVP,therewerenostatisticallysignificantdifferencewithea

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