肝肺综合征发病机制的基础实验分析与临床探讨-basic experimental analysis and clinical discussion on pathogenesis of hepatopulmonary syndrome.docxVIP

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肝肺综合征发病机制的基础实验分析与临床探讨-basic experimental analysis and clinical discussion on pathogenesis of hepatopulmonary syndrome.docx

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肝肺综合征发病机制的基础实验分析与临床探讨-basic experimental analysis and clinical discussion on pathogenesis of hepatopulmonary syndrome

华中科技大华中科技大学博士学位论文综述一····································································································· 72 综述二····································································································· 77 附录········································································································ 95 致谢········································································································ 96 PAGE 10 PAGE 10 中英文缩略词表英文缩写英文全称中文全称 HPS CBDL OJ EC CX3CR1-Ab Hepatopulmonary syndrome Common bile duct ligation Obstructive jaundice Experimental control group CX3CR1-pcAb treated group 肝肺综合征胆总管结扎术梗阻性黄疸实验对照组 CX3CR1抗体治疗组 PIM MVD A-aDO2 AST ALT Pulmonary intravascular macrophages Microvessel density Alveolar-artery oxygen difference Aspartate transaminase Alamine aminotransferase 肺血管内巨噬细胞微血管密度肺泡动脉氧分压差天门冬氨酸转氨酶丙氨酸氨基转移酶 ALP TBIL HBM CK-MB BUN Alkaline phosphatase Total bilirubin Hyperbilirubinemia Creatine kinase isoenzyme Blood urea nitrogen 碱性磷酸酶总胆红素高胆红素血症肌酸激酶同工酶血液尿素氮 Crea ET ETM ET-1 TNF-α Creatinine Endotoxin Endotoxemia Edothelin-1 Tumor necrosis factor-α 肌酐内毒素内毒素血症内皮素1 肿瘤坏死因子 MVB1 SAM STS Methionine and Vitamin B1 S-adenosylmethionine Sodium Tanshinone IIA Sulfonate 甲硫氨酸维 B1 S-腺苷蛋氨酸丹参酮ⅡA 磺酸钠 ELISA HE IHC IF Enzyme-linked immuno sorbent assay Hematoxylin and eosin stain Immunohistochemistry Immunofluorescence 酶联免疫吸附测定苏木素-伊红染色免疫组化免疫荧光 PCR Polymerase Chain Reaction 聚合酶链反应 NO Nitric oxide 一氧化氮 NOS Nitric oxide synthase 一氧化氮合酶 iNOS induced Nitric oxide synthase 诱导型一氧化氮合酶 eNOS Endothelia Nitric oxide synthase 内皮型一氧化氮合酶 cNOS constitutive NOS 原生型一氧化氮合酶 nNOS nervous Nitric oxide synthase 神经原性 NOS CO Carbon monoxide 一氧化碳 HO-1 Heme oxygenase-1 血红素氧合酶 MDC Macrophage derived chemokine 巨噬细胞定位趋化因子 DC Dendrtic cells 树突状细胞 PDGF Platelet derived growth factor 血小板衍化生长因子 VEGF Vascular endothelial growth factor 血管内皮生长因子 VEGFR Vascular endothelial growth factor receptor 血管内皮生长因子受体丝氨酸／苏氨酸蛋白激 Akt P