血清opn try-2 ca199 ca125与胰腺癌的相关性分析-correlation analysis between serum opn try - 2 ca 199 ca 125 and pancreatic cancer.docxVIP

血清opn try-2 ca199 ca125与胰腺癌的相关性分析-correlation analysis between serum opn try - 2 ca 199 ca 125 and pancreatic cancer.docx

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血清opn try-2 ca199 ca125与胰腺癌的相关性分析-correlation analysis between serum opn try - 2 ca 199 ca 125 and pancreatic cancer

床分期I期:35.65±8.95,8.14±1.55,185.48±23.26,36.78±2.52;临床分期II期:49.72±7.25,10.18±2.06,143.62±62.92,48.92±3.65;临床分期III期:59.95±9.78,14.42±3.32,288.45±71.18,60.75±8.52;临床分期IV期:70.42±6.58,18.95±4.18,326.58±80.85,71.45±10.61;组间比较差异具有统计学意义,P均0.05);合并淋巴结转移者上述指标均明显高于无淋巴结转移者(合并淋巴结转移者:68.44±11.95,17.96±4.21,295.76±81.52,69.15±9.78;无淋巴结转移者:41.48±9.52,10.44±3.62,195.85±43.65,35.46±2.25;t=6.54,5.22,83.88,11.66,P0.05)。Spearman秩相关分析法分析结果显示,胰腺癌患者血清OPN、Try-2、CA199、CA125水平与其临床分期呈正相关(r=0.792,0.765,0.743,0.755,P0.05),淋巴结转移也均呈正相关(r=0.765,0.778,0.751,0.749,P0.05)。结论:?血清OPN、Try-2、CA199、CA125在胰腺癌患者血清中显著增高。?血清OPN、Try-2、CA199、CA125水平检测均对诊断胰腺癌具有一定价值,联合四者水平检测,对胰腺癌诊断的特异性和敏感性高,误诊率和漏诊率较低,具有较高临床价值。?血清OPN、Try-2、CA199、CA125水平均与胰腺癌的临床病理特征相关,提示四者对预测胰腺癌病情程度具有重要的意义。【关键词】胰腺癌;骨桥蛋白;人胰蛋白酶原2;癌抗原199;癌抗原125IIIRelationshipbetweenserumOPN,Try-2、CA199、CA125andpancreaticcancerMajor:surgery(general)Postgraduate:YangPengSupervisor:SunChengyiZhaoJianyong[Abstract]Objective:ToinvestigaterelationshipbetweenOsteopontin(OPN),trypsinogen2(Try-2),cancerantigen199(CA199)andcancerantigen125(CA125)withpancreaticcancerthroughdetectingtheirserumexpressionlevel.Methods:30pancreaticcancerpatientsand30healthypersonswhohadphysicalcheck-upinhepticbilesurgerydepartmentofattachedhospitalofGuiyangmedicalcollegefromMarch,2013toOctober,2014wererandomlyselectedastheobjective.30healthypersonswithpersonnelphysicalexaminationwastakenashealthgroupand30patientswithpancreaticcancerweretakenasillgroup.Enzyme-linkedimmunosorbentassay(ELISA)methodwasappliedindetectingofserumOPN,Try-2,CA199andCA125levels.ValueofserumOPN,Try-2,CA199andCA125leveldiagnosingpancreaticcancerandClinicalpathologicalcharacteristicsofpatientswereanalyzedandSpearmanmethodwasappliedinanalysisoftherelationshipbetweenserumOPN,Try-2,CA199andCA125levelswiththeclinicalpathologicalcharacteristicsofpancreaticpatients.Results:(1)SerumOPN,Try-2,CA199andCA125levelsofillgroupweresignificantlyhigherthanthatofthehealthygroup,anddifferenceofserumOPN,Try-2,CA199andCA125levelsoftwogroupswasstatis

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