抑制生理过度觉醒治疗失眠症的临床分析-clinical analysis on treatment of insomnia with inhibition of excessive physiological arousal.docxVIP

EEGElectroencephalogram心电图ECGElectrocardiogram脑电图MSAMedial septal area内侧隔区MPOAMedial preoptic area内侧视前区LFHFLF/HFMeasures HR rhythms from 2.5 to9 cycles/mini.e., 0.04-0.15 Hz,Captures variations in HR due to respiratorysinus arrhythmia at 9-24 cycles/min, i.e.,0.15-0.4 Hz.Average over 5-min periods or less Purported to reflect SNS/PNS balance低频高频低频与高频的比值Clinical research of Inhibit physiological hyperarousal to treat insomniaBackground and Objective:AbstactInsomnia is a disease complaint of Sleep latency extended, maintaining sleep dysfunction, impaired early awakening, that accompanied by the dysfunction during the day. Insomnia has gradually grown into a worldwide problem in recent years. According to the estimates of expert, in 2020 ,there will be 700 million Insomnia patients all over the world .Effective treatments of insomnia contains drug treatment and Cognitive behavioral therapy (CBT).Treatment of drug can’t cure insomnia, and will give rise to significant side effects or drug dependence after taking medicine for a long time. Evidence-based medicine had confirmed that CBT can cure insomnia, however in china, this treatment has not yet been Widely used because of many factors. Therefore, to explore new ways to treat insomnia is urgently. The hyperarousal mechanism of insomnia has been accepted widelyby the researchers at home and abroad, it’s expressed in terms of physiologic ，cognitiveand cortical activation. Physiologic hyperarousal is objectively shown as excessive activation of sympathetic nervous system and hypothalamic–pituitary–adrenocortical system. And is shown as panicky, hyperhidrosis, stress, anxiety, and rise of cortisol accompany with insomnia. Hyperarousal is not only the mechanism and as a result of insomnia, but also maintain factor of it. We hypothesized that if we inhibited hyperarousal,insomnia can be improved. Dexmedetomidine (Dex) can agonism α2 acceptor locate atlocus ceruleus (LC) to inhibit release of Norepinephrine system as an agon