孕期尼古丁对老年子代ras介导的血管功能的分析-analysis of the effect of nicotine during pregnancy on ras - mediated vascular function in the elder offspring.docxVIP

Renin-angiotensin system mediated vascular changes in aged offspring rats exposed to perinatal nicotineAbstract Renin-angiotensin system mediated vascular changes in aged offspring rats exposed to perinatal nicotine AbstractThis study determined the long-term influence of prenatal nicotine exposure (PN) on blood pressure and vascular functions in aged offspring rats. PN did not affect body weight and plasma /s?wd=adrenocorticotropic%2Bhormoneamp;tn=dictadrenocorticotropic hormone level; however, it significantly reduced plasma angiotensin I and angiotensin II in both sexes. Angiotensin II-increased mean arterial pressure was higher in aged PN offspring than that of control group regardless of sex. AT1 receptor blocker losartan, not AT2 receptor antagonist PD123319, reduced blood pressure in the aged PN rats more than that in the control. In the aged PN offspring, angiotensin II-increased vessel contractions were higher in aorta and small mesenteric arteries. Acetylcholine-mediated vascular relaxation was weaker, and nitric oxide-related endothelial functions were damaged in aortic and mensentric rings of PN offspring. Ratio of AT1/ AT2 receptors was significantly increased in the mensentric vessel of the PN group regardless of sex. These data provides new information on the very long term influence of PN on vascular structures and functions in aged offspring, demonstrated that the vascular function and cardiovascular system of aged PN rats were damaged , and suggest that multiple pathways may be involved in detrimental alterations of the cardiovascular system of the PN rats.Keywords: nicotine, vascular functions, aged offspring，Renin-angiotensin systemWritten by : Hehua Tao Supervised by: Caiping Mao Zhice Xu目录引言··························································································· 1 第一部分 材料与方法 ······································································· 6 第二部分 结果 ····································································