不同热休克蛋白比较及其与中医药关系.docVIP

不同热休克蛋白比较及其与中医药关系 　　摘 要:热休克蛋白(Heat Shock Protein,HSP)是一组具有重要生理功能,高度保守的蛋白质分子家族。生理、病理及环境因素等都可诱导热休克蛋白产生,故又称为应激蛋白(Stress Protein) 。根据分子量大小和同源程度, HSPs可分为HSP110、HSP90、HSP70、HSP60、小分子HSP(sHSP)5个主要的家族。目前对HSP90、HSP70研究最多,而对HSP110研究较少。HSPs有许多共同点,但各个HSP家族都有独特的结构和功能。HSPs对机体具有保护性,故设法寻找一种没有毒副作用的HSPs诱导剂或方法,已成为国内外研究的活跃领域。中医中的针灸和中药能影响HSPs的表达,就HSPs的结构功能及其和中医药的关系做一综述。 　　关键词:热休克蛋白;结构;功能;针灸;中药 ? 　　中图分类号:R456 文献标识码:A 文章编号:1673-7717(2010)04-0718-03 　　Comparison of Different Heat Shock Proteins and Their Relationship with the Chinese Medicine 　　HUANG Yun,Advisor:LING Ya?ping ??　(Department of Acu-moxibustion and Massage,Hunan College of Chinese Medicine,Changsha 410208,Hunan,China) 　　Abstract:Heat shock protein is a group of highly conserved protein molecules family who has important physiological functions. Physiology, pathology and environmental factors can be induced by heat shock protein production, it is also known as stress proteins. According to molecular size and degree of homology, HSPs can be divided into HSP110, HSP90, HSP70, HSP60, small molecular HSP family of five major. Current,We studied HSP90, HSP70 most, but few on the HSP110. HSPs have much in common, but each HSP family has a unique structure and function. HSPs can protect the body , so try to find a no toxic side effects of HSPs induction agent or method has become an active area of research at home and abroad. Acupuncture and Chinese medicine of Traditional Chinese Medicine can affect the expression of HSPs.We make a review aboutthe structure、function of the HSPs and the relationship with Chinese medicine. ? 　　Key words:heat shock protein ; structure; function ; acupuncture Chinese medicine 　　 　　收稿日期:2009-11-11 　　基金项目:国家自然科学基金资助项目)国家教育部博士点科研基金资助项目(20070541003) 　　作者简介:黄芸(1984-),女,湖南耒阳人,硕士研究生,研究方向:经脉脏腑相关机理研究。 　　通讯作者:林亚平(1956-),女,湖南长沙人,教授,硕士研究生导师,研究方向:经脉脏腑相关机理研究。 　　 热休克蛋白(heat shock proteins, HSPs)是Ritossa在1962年首先发现的,当时在研究果蝇唾液腺染色体时发现一种在细胞高温应激时能产生对细胞有保护作用而且高度保守的蛋白质[1]。HSPs每个家族针对不同的亚细胞结构都有组成性和诱导性表达