丹红注射液对急性脑梗死患者脑循环动力学影响临床研究.docVIP

丹红注射液对急性脑梗死患者脑循环动力学影响临床研究 　　【摘要】 目的 为观察和研究丹红注射液治疗急性脑梗死患者的疗效及对脑循环动力学的影响。方法 对86例该病患者进行脑循环动力学观察，采用随机、双盲和平行对照的方法，把患者分为两组，同样接受脑梗死的基本治疗的基础上，治疗组用生理盐水250 ml加入丹红注射液20 ml，静脉滴注， 1次/d；对照组用生理盐水250 ml加入复方丹参注射液20 ml，静脉滴注，1次/d，均以14 d为1个疗程。对患者进行丹红注射液治疗前、治疗后的脑神经功能缺损评分，同时测定脑循环动力学参数(CVDI)。结果 ①丹红注射液组神经功能缺失，治疗组有效率为90．7％，对照组为79．1％；②丹红注射液组患者病灶一侧CVDI中，脑血流量(Q)及血流速度(V)用丹红注射液治疗后较治疗前显著增加(P 　　【关键词】丹红注射液；脑梗死；脑循环动力学参数 　　?? 　　Clinical research of danhong injection on cerebral hemodynamics in patients with acute cerebral infarction 　　 　　ZHANG Jian-bin,ZHANG Li-ling,WANG Su-fang,et al.Department of Neurology,Heji Hospital Affiliated to Medical college of Shanxi, Changzhi 046000, China 　　? 　　【Abstract】 Objective To observe and study the clinical efficacy of danhong injection and its effect on cerebral hemodynamics in patients with acute cerebral infarction ，we choose 86 patients in our hospital in research of cerebral hemodynamics.Methods This clinical trial was randomly double-blind and parallel controlled．The patients were divided into two groups．All patients recieved same basic treatment；The treatment goup was trented by physiological saline(250 ml) plus danhong injection(20 ml) with mainline one time each day.The contrast goup was trented by physiological saline(250 ml) plus fufangdanshen injection(20 ml) with mainline one time each day.The period of trentment is 14 days.then scoring the condition of neural functional deficits before and after the treatment；at the same time the cerebrovascular dynamics index(CVDI) of the patients were measured.Results ①The neural functional deficits of patients in trial group tended to be repaired．The effective rate (ER) was 90．7％，but the control group’s ER was 79．1％．②The total cerebral blood flow and velocity(V)in the focal side of brain after the treatment in the treatment group showed a statistically significant increase，compared with those before the treatment (P 　　1．2 入选标准 全部病例均符合1995年全国第四届脑血管病学术会议制定的诊断标准[1]。经临床与头颅CT 或头颅磁共振成像(MRI)确诊为脑梗死。排除标准