Kinetic Theory for the Dynamicsof Fluctuation-Driven Neural 用于驱动的神经表现波动动力学理论.ppt

?t ?(v) = ?-1?v [(v – VR) ?(v) + ?1(v)(v-VE) ?(v)] ?t ?1(v) = - ?-1[?1(v) – G(t)] + ?-1{[(v – VR) + ?1(v)(v-VE)] ?v ?1(v)} + ?g2 / (??(v)) ?v [(v-VE) ?(v)] Together with a diffusion eq for ?(g)(g,t): ? ?t ?(g) = ?g {[g – G(t)]) ?(g)} + ?g2 ?gg ?(g) PDF of v Theory→ ←IF (solid) Fokker-Planck→ Theory→ ←IF ←Mean-driven limit ( ): Hard thresholding Fluctuation-Driven Dynamics N=75 N=75 σ=5msec S=0.05 f=0.01 firing rate (Hz) PDF of v Theory→ ←IF (solid) Fokker-Planck→ Theory→ ←IF ←Mean-driven limit ( ): Hard thresholding Fluctuation-Driven Dynamics N=75 N=75 σ=5msec S=0.05 f=0.01 Experiment firing rate (Hz) Mean-Driven: Bistability and Hysteresis Network of Simple, Excitatory only Fluctuation-Driven: N=16 Relatively Strong Cortical Coupling: N=16! Mean-Driven: N=16! Bistability and Hysteresis Network of Simple, Excitatory only Relatively Strong Cortical Coupling: Computational Efficiency For statistical accuracy in these CG patch settings, Kinetic Theory is 103 -- 105 more efficient than IF; Realistic Extensions Extensions to coarse-grained local patches, to excitatory and inhibitory neurons, and to neurons of different types (simple complex). The pdf then takes the form ??,?(v,g; x,t), where x is the coarse-grained label, ? = E,I and ? labels cell type Three Dynamic Regimes of Cortical Amplification: 1) Weak Cortical Amplification No Bistability/Hysteresis 2) Near Critical Cortical Amplification 3) Strong Cortical Amplification Bistability/Hysteresis (2) (1) (3) Excitatory Cells Shown Firing rate vs. input conductance for 4 networks with varying pN: 25 (blue), 50 (magneta), 100 (black), 200 (red). Hysteresis occurs for pN=100 and 200. Fixed synaptic coupling Sexc/pN Summa