Stable Propagation of Synchronous Spiking in Cortical Neural 同步脉冲的稳定传输皮质神经.ppt

Stable Propagation of Synchronous Spiking in Cortical Neural 同步脉冲的稳定传输皮质神经.ppt

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Stable Propagation of Synchronous Spiking in Cortical Neural 同步脉冲的稳定传输皮质神经

Stable Propagation of Synchronous Spiking in Cortical Neural Networks Markus Diesmann, Marc-Oliver Gewaltig, Ad Aertsen Nature 402:529-533 Outline Background Neural Code IntegrateFire Neuron Motivation / Research Questions Methods Results Discussion Conclusions The Neural Code The Neural Code Independent-spike versus correlation code. Temporal versus rate code. The Neural Code Independent-spike code Time-dependent firing rate r(t). Probability distribution of spike times can be computed from r(t) as inhomogenous Poisson process. Firing rate r(t) contains all information about stimulus. Interspike intervals do not carry information. The Neural Code Correlation code Correlation between spike times carry information. e.g. information about stimulus carried by interspike intervals. The Neural Code Rate code Assumption: independent-spike hypothesis fulfilled. Firing rate r(t) “varies slowly with time”. Temporal code Assumption: independent-spike hypothesis fulfilled. Firing rate r(t) “varies rapidly”. “Information is carried by spike timing on a scale shorter than fastest time characterizing variations of stimulus.” Requires precise spike timing ? millisecond precision possible for noisy neurons? Motivation / Research Questions High temporal accuracy observed in vivo (precisely timed action potentials related to stimuli and behavioral events in awake behaving monkey, e.g. Abeles 1993) and in vitro. “Can instances of synchronous spiking be successful transmitted/propagated by subsequent group of neurons?” “Under which conditions?” Integrate Fire Neuron I No biophysical states (channel dynamics). Integrate transmembrane currents. If threshold reached: Stipulate action potential (AP). Reset membrane voltage below threshold. Integrate Fire Neuron II Leaky integratefire (if) neuron: Network Topology Feedforward architecture. Group = layer. Predictions “Neurons that share a large enough pool of simultaneously discharging input cells tend to align their action pote

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