杨建伟结直肠癌的个体化治疗2010.12.3PPT.pptVIP

结直肠癌的个体化治疗;大肠癌的治疗进展;NCCN V.2. 2010 recommendations for first-line treatment of mCRC;Colorectal Cancer Tumorigenesis ;*;Microsatellite lnstability Is a Favorable Prognostic lndicator in Patients With Colorectal Cancer Receiving Chemotherapy;Molecular Assessment of Response in Disseminated Disease;5-FU的疗效预测指标;  Thymidylate Synthase (TS)  ;Thymidylate Synthase;;Molecular Assessment of Response in Disseminated DiseaseTS:QUANTITATION IN DISSEMINATED COLORECTAL CANCER;5-FU的疗效预测指标;Thymidine Phosphorylase;Thymidine Phosphorylase;5-FU的疗效预测指标; Dihydropyrimidine Dehydrogenase ;5-FU的疗效预测指标;Molecular Assessment of Response in Disseminated DiseaseResponse to CI 5-FU in colon cancer: Effect of TS, TP, and DPD;TS TP DPD小结;OXA的疗效预测指标;TS and ERCC-1 in GI Tumors Molecular Markers Resistance/Sensitivity ;ERCC-1 and repair in Colorectal Cancer;OXA的疗效预测指标;3. Hahn K, et al. Am J Health-Syst Pharm. 2006;63(22):2211-2217;Toxicities;UGT1A1;UGT1A1*28 and Toxicity;Innocenti et al. ;“ Individuals who are homozygous for the UGT1A1*28 allele are at increased risk for neutropenia following initiation of CAMPTOSAR treatment. A reduced initial dose should be considered for patients known to be homozygous for the UGT1A1*28 allele. ”;CPT-11的毒性预测指标;So what do we do in practice …;CPT-11的毒性预测指标;;CPT-11的疗效预测指标;西妥昔单抗的疗效预测指标;K-RAS mutation and Resistance;西妥昔单抗的疗效预测指标;Impact of mutations in the PIK3CA signal transduction pathway;Impact of mutations in the PIK3CA signal transduction pathway;Impact of mutations in the BRAF signal transduction pathway;西妥昔单抗的疗效预测指标;西妥昔单抗的疗效预测指标;贝伐单抗的疗效预测指标;CRC术后辅助化疗的预测指标;总 结;谢 谢