医学课件信号传导的病理生理学.pptVIP

The ancestral relationships among PRAK related kinases Activation of endogenous PRAK by various stimuli in vivo Effect of individual MAPK pathways on PRAK activity in intact cells Effects of SB203580 and PD98059 on endogenous PRAK activity Types of Interactions(courtesy of K. Kohn) Systems Biology: A New Paradigm Understanding from Systems Biology Platform for Systems Biology Induction of c-Jun through MEF2C phosphorylation by p38 MKK4 MKK3 MKK6 Cytokine Genes Expression LPS p38 p38 JNK JNK MEF2C c-Jun MEF2C c-Jun MEF2 site c-Jun Gene Expression TNF,IL-1,etc. Inflamatory Reaction AP1 p