免疫学课程1PPT.pptxVIP

1;2;Natural Killer cells: Artifact to reality ;The phenomenon of cell-mediated immunity or reactivity as measured by cellular cytotoxicity assays was reasonably “well defined” in the early 1970s The immunologic dogma at that time stated that tumor-related, cell-mediated cytotoxic reactions were due to tumor-associated antigens to which T lymphocytes had become previously sensitized Occasional normal individuals showed reactivity against tumor cell lines in vitro, but this reactivity was often felt to be artifactual or due to technical problems in the assay. It was apparent by 1972 that sever