细胞分化与癌细胞（医学）.pptVIP

p53的作用：基因组的卫士 DNA 损伤起始由肿瘤抑制基因和原癌基因编码的许多蛋白质的活性 DNA damage checkpoint: Cell-cycle progression is blocked by DNA damage and p53 DNA损伤是如何使细胞周期中止在G1期 Two such checkpoints: 1.One in late G1: prevents entry into S phase; 2.One in late G2: prevents entry into mitosis; p53: gene regulatory protein. DNA damage activates p53 by an indirect mechanism. Mdm2 acts as a ubiquitin ligase that targets p53 for destruction by proteasomes. Phosphorylated p53 reduce its binding to Mdm2. p21(CDKI protein) binds to G1/SCdk and S-Cdk and inhibits their activities, thereby helping to block entry into S phase. 抑癌基因与