【精品英文课件】Stature in adolescent twins.pptVIP

Polygenic Traits Complex Trait Model Linkage = Meiotic co-segregation HapMap: View variation patterns The International HapMap Project(Identification of SNPs that ‘tag’ haplotypes within blocks) Drilling down to the “QTN” (“Quantitative Trait Nucleotide”) Haplotype “block” is the lower limit of resolution of marker-on-trait mapping. Switch to studies of associated variants: In cella. E.g., transfected/expressed variants. In vitro. E.g., kinetic properties of variants. In vivo: transgenic mice (BAC haplotype variant expression on knockout background). Figure 7: Intermediate phenotypes