超级细菌的发现、演变、结构、发病机理及预防（英文PPT）课件.pptVIP

Purpose of slide: To discuss the unique mechanism of action of daptomycin. In viable bacteria, the polarized state of the cytoplasmic membrane results from the maintenance of ion and proton gradients across the bilayer of the plasma membrane. One of the most prominent gradients involves potassium (K+), with high intracellular and low extracellular concentrations. Mechanism of action (MOA) of daptomycin: Step 1: Daptomycin inserts into the cytoplasmic membrane of bacteria. This step is calcium-dependent, as indicated by whole cell and in vitro studies. Step 2: An ion-conduction structure (eg,