应用纳米技术构建生物支架修复脊髓损伤的实验研究 上海交通大学.pdfVIP

本研究的第二部分中，通过将转染hNGF基因的SCs种植到三维支架上，一起移 植至脊髓损伤处，观察脊髓轴突再生及脊髓传导功能恢复情况。结果发现，植入体内 的SCs保持良好的生物活性并可存活3个月以上，hNGF基因得到持续表达，三维支 架3个月后吸收，脊髓损伤处发现新生的轴突和突触，脊髓的神经功能得到部分恢复。 关键词：脊髓损伤；组织工程技术；NGF基因：重组慢病毒；纳米技术；聚乙交酯一 丙交酯；雪旺细胞 3 Absorbablescaffold constructedwithnanameter to of cord techniquepromoteregeneration inj spinal ury Abstract With the ofmodem tradeand development industry,transporting incidenceof cord atrendof are spinal injuI)r(scopresents increasingevery year．There some commoncharacteristicoftheSCIaroundtheword．The rates points firstishigh of neurological rateof is costof disfunction(thecompleteparalysis67％)．Second,the healing SCIis isthelow victimofSCIis veryhigh．Third mortality(5％)．Finally,the always is them than40 resultsin youngpeople．40％amongyounger yearsold．So，SCI always of and lossof andcItlrothe hugedamagesocietygreat of and cord of nervecellsarestillthe spinal secondly嫡ury protectionremaining mainstay of withSCI is isbecause keypoints de