食管癌放疗进展.pptVIP

食管癌个体化放疗Advance Challenge  Poly-Targeted Therapy for EPC 放疗疗效取决于：1. 靶区勾画 2. 射线施照 3. 放疗与其它治疗的联合 术前化疗:尚存争议 RTOG 8911/INT133: Phase III 467 Pts with T1-2NxM0 SCC and adenoCA randomized to surgery alone vs. preop chemo×3c PF→surgery. Pre-op chemo did not improve OS Meta-analysis (2007) : Eight randomized studies with 1,724 Pts evaluating chT+S vs. S alone. Pre-op Chemo improved survival in adenoCA, but not in SCC Esophageal Cancer Working Group (2008): Phase III 802 Pts with SCC adeno randomized to surgery alone vs. pre-op chemo×2c PF→surgery. Survival advantage was seen in both adeno