分子和细胞免疫进展02.pptVIP

3. CD8+ T cell suppression and self tolerance Murine EAE Adjuvant-induced arthritis Mouse models of type 1 diabetes Qa-1–specific transplantation tolerance could prevent generation of alloreactive CTL (III) non–Qa-1–restricted CD8+CD28– cells Can suppress immune responses by directly interacting with antigen-presenting DCs and rendering these cells tolerogenic The suppression involves the upregulation of inhibitory Ig-like transcript 3 (ILT3) and ILT4 receptors expressed on the DCs. Specific unresponsiveness in CD4+ T helper cells. The precise function of these cells in viv