雀斑与遗传课件.pptVIP

雀斑的遗传学研究简介 Outline Backgrounds Abstract and Introduction Materials and Methods Results and Discussion Backgrounds Freckles are clusters of concentrated melanin which are most often visible on people with a fair complexion. A freckle is also called an ephelis. 遗传性对称性色素异常症和雀斑的临床特点及遗传方式的研究 安徽医科大学 林国书 Chinese scientists localize freckle gene Chinese scientists have found that freckles, a nuisance for many people, are caused by certain genetic variations. Prof. Zhang and his colleagues used state-of-the-art genome scanning technologies to analyze the samples before they came to the conclusion. Freckles have long been a nuisance for beauty-seeking girls. [file photo] —China daily Updated: 2004-04-11 09:55 The melanocortin-1-receptor gene is the major freckle gene The high prevalence of MC1R gene variants and ephelides and the strong association between these variables indicate that the MC1R gene contributes largely to the etiology of ephelides and suggests the MC1R gene to be the major ephelides gene. Abstract The purpose of this study was to investigate the relationship between MC1R gene variants and ephelides. Abstract In a large case-control study, patients with melanoma and non-melanoma skin cancer and subjects without a history of skin cancer were studied. The entire coding sequence of the MC1R gene was analyzed by followed by sequence analyses. Abstract As nearly all individuals with ephelides were carriers of at least one MC1R gene variant, our data suggest that MC1R gene variants are to develop ephelides. Abstract Introduction Ephelides are small pigmented spots of the skin commonly occuring in the Caucasian population, more frequently in fair-skinned individuals with red or light-blond hair Russian tennis beauty Maria Sharapova, Caucasian Introduction The melanocortin-1-receptor (MC1R) gene plays an important role in the genetics of human pigmentation The human MC1R gene