对严重创伤失血患者进行镇静治疗应用分析.docVIP

对严重创伤失血患者进行镇静治疗应用分析 　　[摘要] 目的 研究对严重创伤失血性患者进行镇静治疗的应用效果和安全性。方法 选择2009年7月～2012年8月期间32例给予异丙酚镇静治疗的严重创伤失血患者作为观察组；另选择同期收治的29例接受常规治疗的严重创伤失血患者作为对照组，观察两组患者48 h内的生命体征、重要脏器指标、应激水平以及免疫功能情况。 结果 两组患者一般资料无显著差异，两组患者治疗后的HR和MAP均得到明显改善，而观察组患者24 h的HR显著低于对照组，6 h的MAP显著高于对照组；两组患者治疗后的ALT和Cr均明显下降，而观察组患者48 h的ALT显著低于对照组；两组患者治疗后的NE和Cor均明显降低，观察组患者24、48 h的NE和48 h的Cor均显著低于对照组；两组患者治疗后的Glu明显降低，观察组治疗后6 h的Glu显著低于对照组。结论 严重创伤失血患者早期可能出现应激反应以及重要脏器功能异常，镇静治疗可以??效调节应激反应，从而达到保护脏器功能，提高疗效的作用。 　　[关键词] 严重创伤；失血；镇静；异丙酚；应激反应 　　[中图分类号] R641 [文献标识码] B [文章编号] 1673-9701（2013）36-0149-03 　　Application analysis of sedation therapy on severe traumatic hemorrhagic patients 　　JI Bo1 WANG Limin1 WANG Jieliang1 Hong Xiaozhen2 　　1.Emergency Center， Xinchang County Peoples Hospital in Zhejiang Province， Xinchang 312500， China； 2.Disease Prevention Control Center of Zhejiang Province， Hangzhou 310051， China 　　[Abstract] Objective To study the applied effect and safety of sedation therapy on severe traumatic hemorrhagic patients. Methods Thirty-two patients with severe traumatic hemorrhage receiving propofol sedation therapy from July 2009 to August 2012 were selected as observation group， another 29 patients with severe traumatic hemorrhage receiving conventional therapy were selected as control group. The vital signs， important organ indexes， stress level and immune functions of patients between two groups were observed and compared within 48 h. Results The general clinical date had no significant difference in two groups， both HR and MAP in all patientsimproved significantly after treatment， whereas the HR after 24 h in the observation group was significantly lower than that of control group， but MAP after 6 h was obviously higher than that of control group. The ALT and Cr of two groups significantly decreased after treatment， while the ALT after 48 h in the observation group was significantly lower than that in the control group. Both NE and Cor conspicuously decreased after treatment， while the NE level after 24 h and