阿那曲唑治疗绝经后乳腺癌继发骨质疏松的预测模型与应用性分析.docVIP

阿那曲唑治疗绝经后乳腺癌继发骨质疏松的预测模型及应用性分析 作者姓名 作者单位 【摘要】目的：搜集患者的相关临床指标，构建预测模型以评判继发, OP)的预测价值，并。 方法：连续性纳入2013年05月至2014年04月期间医院的患者为队列搜集相关临床资料，对其进行为期的随访以确认预后转归。依据随访结果预判继发风险的影响性指标，并验证应用性。 结果：最终搜集252例符合本次临床试验要求的患者75例患者继发、165例患者于随访期内常①Cox回归分析显示，alkaline phosphates, ALP)含量组成，其中绝经时间及服用阿那曲唑时间为危险性因素，服用双磷酸盐时间及ALP含量为保护性因素；②3.017年、＜1.878患者，继发的时间窗更短，具有评判效能。 结论：是的独立影响因素，且3.017年、＜1.878为衡量患者继发的。 【关键词】、、 Predictive model and application of anastrozole in the treatment of postmenopausal breast cancer secondary to osteoporosis Author’s name Author’s unit 【Abstract】Objective: To collect postmenopausal breast cancer patients taking anastrozole after the relevant clinical indicators, The predictive model was established to evaluate the predictive value of secondary osteoporosis (OP), and then verify its applicability. Methods: Continuity included in the period from May 2013 to April 2014 in Wuhan City Center Hospital treated with anastrozole endocrine therapy for postmenopausal breast cancer patients for the study of the cohort, the clinical data were collected and followed for a follow-up of 36 months to confirm prognosis. According to the follow-up results predictive secondary risk of OP risk indicators, and analyze the secondary OP time window to verify the applicability of the prediction model. Results: The final collection of 252 cases of breast cancer patients in line with the clinical trial requirements, of which 12 patients were lost, 75 patients secondary to OP, 165 patients in the follow-up period of bone mineral density normal or relatively normal. ①Cox regression analysis showed that the independent influencing factors of adjuvant OP in patients with postmenopausal breast cancer were determined by the time of menopause, the time of taking anastrozole, the time of bisphosphonates, the contents of alkaline phosphates (ALP) Among them, menopause time and taking anastrozole time as a risk factor, taking bisphosphonates time and ALP content as protective factors; ②taking anastrozole time≥3.07