囊尾蚴病精品课件.pptVIP

Scrub Typhus（恙虫病）Department of Infectious Diseases, the Third Affiliated HospitalLi Gang Definition Acute febrile infectious disease Caused by Rickettsia tsutsugamushi Transmitted by the bite of chiggers Source of infection: Rats Characterized by fever, eschar, rash, and lymphadenopathy Etiology Intracellular organism Propagated in mice, some cells Antigenically diverse microorganism Common antigen with Proteus OX-K Low resistance Epidemiology ▲ Source of infection: Rats ▲ Vector: Mite The life cycle: ovum, larva, pupa, naiad and imago Only its larva (chigger) feeding on humans imago larva rat pupa naiad imago ovum larva rat pupa naiad 第一代 第二代 (遗传、传染) The life cycle of mite bite ovum Epidemiology Proliferate in warm, wet environments Both a vector and a reservoir ▲ Route of transmission: bite of chigger ▲ Susceptibility: universal ▲ Immunity: long-lasting immunity against the homologous strains; Partial immunity against the other heterologous strains Epidemiology ▲ Other epidemiological features: Geographic distribution: Asian-pacific region Sporadic Seasonal distribution: rainy seasons between May and November Pathogenesis human body rickettsemia eschar local site rickettsia mite vasculitis rats Pathology Basic lesion: inflammation of the walls of the small blood vessels Pathologic findings: eschar, lymphadenopathy, rash, enlargement of spleen and liver Serious pathologic manifestations: myocarditis, meningoencephalitis, pneumonia, interstitial nephritis Clinical manifestations Incubation period: 4～21 days Sudden onset, High fever: remittent fever accompanied by chill, headache, malaise, prostration, poor appetite. Clinical manifestations Signs of multiorgan damage: Meningoencephalitis: delirium, convulsion, coma, and neck stiffness. Interstitial pneumonia: cough, chest pain, breathlessness. Clinical