2014结节性筋膜炎课件.ppt

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2014结节性筋膜炎课件

* * Grossly this example of nodular fasciitis forms a whitish, fleshy mass of approximately 2 cm, with a central cyst. * Lowmagnification appearance of nodular fasciitis. (A,B)Two examples of variably circumscribed lesions.(C,D) Two examples of the infiltrative (“repair”)variant of nodular fasciitis. * Typical histologic features of moderately cellular variants of nodular fasciitis. Microcystic degeneration and clefts (A,D), moderate deposition of collagen (A–D),osteoclast-like giant cells (B,C), extravasated erythrocytes (D), and occasional mitotic activity (C,D). * Variants of nodular fasciitis that could be related to the duration of the lesion. (A,B) Myxoid “early” example with prominent deposition of extracellular mucin. (C,D)A fibrous “late” example with relatively low cellularity and prominent collagen deposition. * Extremely cellular “pseudosarcomatous”example of nodular fasciitis with numerous mitotic figures. (A) Focal collagenous maturation is present in the lesion periphery. (B,C) The tumor is highly cellular but contains cleavage spaces,extracellular mucin, and scattered osteoclastic giant cells typical of nodular fasciitis.Numerous mitoses are present (C,D). * Examples of repair variant of nodular fasciitis with granulation tissue–like morphology.Note the poorly circumscribed nature of the process, prominent arcades or newly formed capillaries, fat infiltration,and collagenous maturation. * * (A) Low magnification reveals a sharply demarcated intramuscular nodule with two small satellite nodules to its left. (B,C) The lesion periphery shows an infiltrative border. (D) High magnification shows multinucleated regenerative skeletal muscle cells (sarcoplasmic giant cells) intermingling with lesional myofibroblats. * Four low-magnification examples of intravascular fasciitis growing inside small veins. * Intravascular fasciitis can be similar to typical nodular fasciitis (A,B), but some examples are rich in osteoclastic giant cells (C,D). * * Loosely tex

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