缺血性脑卒中机理以及新药研究进展概要1.pptx

The science of ischemic stroke:;What is cerebral ischemic stroke What cause cerebral ischemic stroke What are the prominent mechanisms of stroke Current approaches for stroke therapeutics ;Cerebral ischemic stroke;Stroke is responsible for 9% of deaths worldwide, making it the second most common cause of mortality . More than 25% of stroke survivors become permanently disabled and lose independence in performing day-to-day activities .These figures will continue to rise with the population living longer than previous generations. As such, effective treatments for stroke are urgently needed.;Stroke Risk Factors and Triggers;Mechanisms of Stroke ;;Mitochondrial response;Reactive oxygen species (ROS); Endoplasmic reticulum stress;Inflammatory ;Current approaches for stroke therapeutics ;Blocking Excitotoxic Events.;;Noncompetitive NMDA Antagonists ; Preclinical Output ; Preclinical Output ;PhaseIII;Clinical Output;TABLE2:Examples of proposed neuroprotective attempts to against oxidative stress;Mechanisms:Proposed interaction of edaravone with free radicals. ; Preclinical Output;Preclinical Output ;Preclinical Output; Clinical Output Edaravone ameliorated the size of ischemic stroke lesions and neurological deficits in patients with small-vessel occlusion, i.e. lacunar infarction, within 1 year, while there were no significant differences in outcome after 1 year. In a study comparing edaravone and citicoline in acute ischemic stroke, edaravone wasmore effective with a better neurological outcome at 3 months than citicoline ;Clinical Output;;LOREM; Time window;Future Directions;1. Moskowitz MA1,?Lo EH,?Iadecola C. The science of stroke: mechanisms in search of treatments.Neuron.?2010 Jul 29;67(2):181-98. doi: 10.1016/j.neuron.2010.07.002 2. Kinga Szydlowska a,b, Michael Tymianski. Calcium, ischemia and excitotoxicity Cell?Calcium.?2010 Feb;47(2):122-9. doi: 10.1016/j.ceca.2010.01.003. Epub 2010 Feb 18. 3. George PM1,?Steinberg GK2. Novel?Stroke?Therapeutics:?Unra