探讨甲基泼尼松龙冲击递减疗法治疗小儿重症过敏性紫癜临床疗效.docVIP

探讨甲基泼尼松龙冲击递减疗法治疗小儿重症过敏性紫癜临床疗效 　　【摘要】 目的：研究分析甲基泼尼松龙冲击递减疗法治疗小儿重症过敏性紫癜的临床疗效。方法：选取2005年5月-2013年7月本院儿科收治的160例重症HSP患儿作为研究对象，根据随机数字表法将所有患儿分为对照组和观察组各80例，其中对照组采用常规地塞米松治疗，一段时间待病情明显改善后，改服与观察组相同剂量的泼尼松，根据病情的恢复程度，逐渐减量至停用；观察组给予甲基泼尼松龙冲击递减疗法进行治疗。观察比较两组患儿的关节肿痛缓解时间、腹痛缓解时间、肾脏损害恢复时间、皮肤紫癜复发情况、紫癜消退时间、消化道出血时间。并对其进行各项常规检查，主要包括免疫球蛋白及补体、尿常规、大便常规、肝肾功能等检查，记录不良反应的发生情况。结果：观察组患儿的各种症状消退时间均明显短于对照组，且皮肤紫癜复发率和不良反应发生率均明显低于对照组，差异均有统计学意义（P 　　【关键词】 甲泼尼龙； 冲击递减疗法； 小儿重症过敏性紫癜； 临床疗效 　　The Clinical Efficacy of Methylprednisolone Diminishing Shock Therapy in the Treatment of Children with Severe Allergic Purpura/LI Ming-xin，CHEN Wei-xia，CHEN Wei-jie.//Medical Innovation of China，2014，11（12）：057-059 　　【Abstract】 Objective：To research and analyze the clinical efficacy of methylprednisolone diminishing shock therapy in the treatment of children with severe allergic purpura.Method：160 children with severe HSP in department of pediatrics from May 2005 to July 2013 were selected as research objects，they were randomly divided into the control group and the observation group，80 cases in each group.The control group was given routine dexamethasone treatment，for a period of time after being condition improved obviously，taken the same dose of prednisone，according to the condition of recovery degree，gradually reduced to stop.The observation group was given methylprednisolone diminishing shock therapy.The joint swelling and pain relief time，abdominal pain relief time，kidney damage recovery time，the recurrence of skin purpura，purpura subsided time and gastrointestinal bleeding time between the two groups were observed and compared.The routine inspection was mainly included the immunoglobulin and complement the urine routine，stool routine，liver and kidney function and so on.And recorded the occurrence of adverse reactions.Result：All symptoms subsided time of the the observation group were significantly shorter than the control group，and skin purpura recurrence rate and the incidence of adverse reaction were significantly lo