Pathway Logic通路逻辑.ppt

  1. 1、本文档共22页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
Pathway Logic通路逻辑

Pathway Logic Symbolic Analysis of Biological Signaling Introduction Tremendous growth of genomic sequence information combined with technological advances in the analysis of gene expression has revolutionized research in biology and biomedicine Investigation of signaling and metabolic pathways would benefit greatly from the use of predictive models Although these pathways are complex, fundamental concepts that stemmed from contemporary research indicates that they are also amenable to analysis via computational methods. E.g. most signaling pathways involved hierarchical assembly in space and time of multi-protein complexes that regulate the flow of information via stimulation or inhibition Introduction Various models have been proposed that incorporates quantitative information such as rate and/or concentration information However they are limited due to the difficulty in obtaining the relevant parameters e.g. Michaelis constant etc. as well as stochastic features of signaling molecules Hence another way to look at such pathways is by the logic of signal, e.g. use of π-calculus to represent and forward simulate signaling pathway In this paper, we will look at the development of logical models based on the application of formal methods tools to mammalian signaling pathways Levels of Abstraction Continuous Abstraction Involves continuous mathematics such as differential equations and are analyzed using sophisticated numerical computational packages However the complexity of biological processes limits its accuracy and effective description Discrete Abstraction Natural processes are described by purely symbolic expressions Applicable to less predictable phenomena such as biological signaling processes (as we shall see later on) Pathway Logic Pathway Logic – an algebraic structure enabling the symbolic analysis of biological signaling pathways It uses rewriting theories to formalize the ‘informal’ models that biologists use to describe processes Advantages of u

文档评论(0)

wuyoujun92 + 关注
实名认证
内容提供者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档