中西药对照治疗病态窦结综合征临床疗效观察.docVIP

中西药对照治疗病态窦房结综合征临床疗效观察 作者：刘金凤　刘如秀　刘志明 【摘要】 ：目的 观察中西药治疗病态窦房结综合征的临床疗效。方法 将171例确诊为病态窦房结综合征患者随机分为治疗组和对照组,治疗组(90例)予强心复脉合剂口服,对照组(81例)予阿托品口服,疗程4周。治疗结束后比较2组的临床症状、24 h动态心电图和左心室射血分数(LVEF)的变化。结果 临床疗效：治疗组和对照组比较,差异有显著性意义(Plt;0.01)；24 h动态心电图：治疗组和对照组心率提高总有效率分别为92%和36%,24 h平均心率分别增加10次/min和4次/min,2组差异有显著性意义(Plt;0.01)；LVEF：治疗组与对照组治疗后比较,有明显改善心功能的作用(Plt;0.01)。结论 强心复脉合剂可以明显改善患者的临床症状、提高心率和改善心功能,是治疗病态窦房结综合征的有效药物。 【关键词】 病态窦房结综合征　强心复脉合剂　临床疗效 　　Abstract：Objective To observe the difference clinical therapeutic efficacy of the Chinese herbal medicine and western medicine on sick sinus syndrome patients. Method 171 patients with sick sinus syndrome were randomly divided into treatment group and control group. 90 patients in the treatment group were given Qiangxin Fumai Mixture while the other 81 patients in the control group were given atropine. The therapeutic course was four weeks in each group. The changes of clinical manifestations, electrocardiogram (24 h Holter monitoring ECG) and left ventricular ejection fraction (LVEF) were compared between two groups. Result Clinical therapeutic efficacy：There was significant difference between two groups (Plt;0.01). 24 h Holter monitoring ECG：The total effective rate of the treatment group was 92% and that of the control group was 36%, with the average increases of heart rates in 24 hours were 10/min and 4/min, respectively. There was significant difference between two groups (Plt;0.01). LVEF：The LVEF in the treatment group was improved evidently compared with that in the control group after treatment (Plt;0.01). Conclusion Qiangxin Fumai Mixture is effective in treating sick sinus syndrome by improving clinical symptoms, heart rates and heart function. 　　Key words：sick sinus syndrome；Qiangxin fumai Mixture；clinical therapeutic efficacy 　 病态窦房结综合征(Sick sinus syndrome)是由于多种病因引起的窦房结或其周围组织变性、坏死、纤维化,导致其起搏功能及传导功能障碍,产生多种心律失常和多种症状的综合征。心律失常以窦性心动过缓、窦房阻滞、窦性停搏为主。常见病因为冠心病、心肌炎、心肌病等,外伤或手术损伤窦房结及其供血的动脉也可引起本病,部分患者病因不明,可能为窦房结特发性退行性病变所致。临床表现为胸闷、心悸、气短、头晕甚则晕厥等。动态心电图显示总