tgf-β,1基因标签单核苷酸多态性与新 疆汉族原发性高血压相关性分析-association between tgf - β, 1 gene tag single nucleotide polymorphism and essential hypertension in xinjiang han nationality.docx

en EH patients and controls (P0.05).(2) rs1800469 CT、TT genotype interact with overweight(CT: OR=2.187,P=0.008；TT:OR=3.778,P=0.000),and obesity(CT:OR=2.643,P=0.006;TT:OR=4.333,P=0.001) ; rs2241716GG genotype interact with overweight(OR=3.030，P=0.007),GA,GG genotype interact wit h obesity(GA:OR=3.977，P=0.004，GG:OR=3.030,P=0.013); rA genotype interact with o verweight(OR=2.788,P=0.000),GA、GG genotype interact with obesity(GA:OR=3.569，P=0.000，GG: OR=19.627，P=0.005), GG genotype interact with drinking(OR=4.864,P=0.045),GA genotype intera ct with male;rs2241715GT、TT genotype interact with overweight(GT:OR=2.589，P=0.002，TT:OR= 4.667,P=0.000), and obesity (GT:OR=3.250,P=0.001,TT:OR=4.861,P=0.000); rs4803455CC genotype i nteract with overweight(OR=2.917,P=0.005), CC、CA genotype interact with obesity(CC:OR=3.558,P =0.003,CA:OR=2.679，P=0.020).(3)Except the site of r the other tSNPs were in strong L D, and no statistical differences were observed in haplotypes distribution in the follow-up study be tween case-control groups (P0.05). The most frequent haplotypes were TGATC(30.5%)、CAAGA(2 4.5%), The frequency of haplotype TGATC、TGGTC、CAGGA、CGGGA、CGGTC in EH group was higher than controls while CAAGA、CGAGA、CGAGC、CGATC、CAGGC、TAGGA was lo wer than controls, But there was no difference between EH patients and controls(P0.05).(4)There were no difference of TGF-β1 levels between the different genotypes and alleles in tSNPs of TGF- β1 gene (P0.05).(5)Oerweight，obesity，abdomen obesity，higher fasting blood sugar and lipid met abolism disorder were environmental predisposing factor for Han EH. Conclusions:(1) Overweight，obesity，abdomen obesity，total cholesterol, low-density lipoprotein an d higher fasting blood sugar were environmental predisposing factor for EH patients in Xinjiang H an, (2)TGF-β1 rG allele was likely to be the genetic susceptibility factors for EH in th e Xinjiang Han and interact with drinks，gender,overweight，obesity.(3) The rs180046