SPECTCT 99mTcOctreotide同机断层融合显像诊断肺癌价值.docVIP

SPECT/CT 99mTcOctreotide同机断层融合显像诊断肺癌的价值 【摘要】 目的 探讨 99mTcOctreotide生长抑素受体显像诊断肺癌的价值。方法 43例肺部肿瘤病人，静脉注射 99mTcOctreotide 15 min、1 h、3 h后行前后位平面显像，2～3 h行SPECT/CT同机断层融合显像。勾画感兴趣区，分别测定肿瘤和对侧正常肺组织的放射性比值(T/N)，并将影像最终诊断结果与病理检查结果进行对比分析。 结果 99mTcOctreotide显像诊断肺癌的灵敏度、特异度和准确度分别为94.4%、85.7%和93.0%。小细胞肺癌（SCLC）的T/N值高于非小细胞肺癌(NSCLC)，差异有显著性(t=6.469,Plt;0.01)。结论 99mTcOctreotide SPECT/CT同机断层融合显像对肺癌具有较高的诊断价值。 【关键词】 肺肿瘤 锝 放射性核素显像 受体 生长抑素 诊断 CLINICAL SIGNIFICANCE OF 99mTcOctreotide LABELLED OCTREOTIDE SOMATOSTATIN RECEPTOR SPECT/ CT FUSION IMAGING IN THE DIAGNOSIS OF LUNG CANCER LIU XINFENG, ZUO SHUYAO, WANG GUOMING, et al (Department of Nuclear Medicine, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China) ［ABSTRACT］ObjectiveTo evaluate the value of 99mTcoctreotide somatostatin receptor scintigraphy in the diagnosis of lung neoplasm. MethodsPatients with pulmonary neoplasm (n=43) were studied with 99mTcOctreotide scintigraphy. Planar imaging was obtained after injection of 99mTcoctreotide at 15 min,1 h,and 3 h，SPECT/ CT fusion images were taken at 2-3 h after injection. All scintigraphically detected lesions were confirmed histopathologically. Ratios of tumor to normal tissue (T/N) were calculated. ResultsSensitivity, specificity and accuracy of 99mTcoctreotide in detection of lung cancer were 94.4%, 85.7% and 93.0%, respectively. The T/N ratio in small cell lung cancer was significantly higher than that in nonsmall cell one (t=6.469,Plt;0.01). Conclusion99mTcoctreotide SPECT/ CT fusion imaging is a good method to detect the primary lung cancer. ［KEY WORDS］lung neoplasms; technetium; radionuclide imaging; receptors, somatostatin; diagnosis 肺癌是最常见的恶性肿瘤之一，其发病率的增长速度在所有癌症中最高，死亡率位居各类恶性肿瘤之首，严重威胁人们的健康。早发现、早诊断、早治疗是关键。一般常规的影像学检查如CT、MRI 等虽能精确定位肿瘤、评估肿瘤范围及大小, 而对肿瘤性质的诊断有时较为困难[1]。生长抑素类似物Octreotide显像诊断肺癌近几年来逐渐受到重视。本研究采用SPECT/CT同机断层实时融合显像技术，对43例肺部包块病人的原发病灶行99mTcOctreotide显像，并将影像诊断结果与病理结果进行对照分析，现报告如下。 1 资料和方法 1.1 一般资料 经CT检查疑为肺部肿瘤病人43例，男30例，女13例，年龄34～76岁，平