不对称15二芳基14戊二烯3酮类化合物的合成及生物活性研究-synthesis and biological activity of asymmetric 15 diaryl 14 pentadiene 3 ketone compounds.docxVIP

3.3目标化合物的合成····················································································273.3.1不对称 1,5-二取代芳基-1,4-戊二烯-3-酮类化合物(IA)的合成 273.3.2不对称 1,5-二取代芳基-1,4-戊二烯-3-酮类化合物(IB)的合成 333.3.3乙基苯基碳酸酯类化合物(II)的合成 343.4目标化合物的生物活性测试方法 ·································································· 363.4.1目标化合物抑菌活性测试方法........................................................................................363.4.2目标化合物体外抗肿瘤活性测试方法.............................................................................36第四章 结果与讨论·······························································································384.1目标化合物合成方法研究···········································································384.1.1目标化合物 I 的合成方法讨论 384.1.2目标化合物 II 的合成方法讨论 394.2目标化合物的波谱解析··············································································404.2.1目标化合物 I 的谱图解析 404.2.2目标化合物 II 的谱图解析 414.3目标化合物的生物活性测定········································································424.3.1目标化合物抑菌活性测试结果........................................................................................424.3.2目标化合物体外抗肿瘤活性测试结果.............................................................................43第五章 结论及展望·······························································································455.1 结论·········································································································· 455.2 创新点········································································································455.3 不足与展望································································································· 45致 谢··············································································································· 46参考文献············································································································ 47附 录··············································································································· 51摘要1,4-戊二烯