【精品】B型肝炎的制药66.ppt

B型肝炎的製藥;Ｂ型肝炎（hepatitis B）病毒性肝炎 ;B型肝炎病毒 ;B肝病毒;Hepatitis B Virus (HBV);B型肝炎表面抗原 ( hepatitis B surface antigen ) ;How the virus reproduces ?;First the virus attaches to a liver cell’s membrane. ;The virus is then transported into the liver cell.;The core particle then releases its contents of DNA and DNA polymerase into the liver cell nucleus. ;Once within the cell nucleus, the HBV DNA causes the liver cell to produce, via mRNA, surface proteins, core protein, DNA polymerase.DNA polymerase causes the liver cell to make copies of HBV DNA from mRNA. ;The cell then assembles copies of the virus. ;However because of the excess numbers of surface proteins produced, many of these stick together to form small spheres and chains.;The copies of the virus and excess surface antigen are released into the blood stream and can infect other liver cells and thus replicate effectively. ;Life cycle;B型肝炎如何致病？ HBV主要的致病機轉並不是直接殺死肝細胞，它是藉 由人體的免疫機轉而導致肝細胞壞死的。人體免疫系 統內的T cell，平常不會攻擊體內的正常細胞，當體內 的正常細胞遭受到病菌感染時，它就會將已受感染的 細胞殺死，目的是為了要除去入侵的病菌。 B型肝炎病毒導致肝炎就是經由這樣的途徑。T cell要 將HBV「驅除出境」，然而HBV是在肝細胞內，所以在T cell欲除去HBV同時，肝細胞也跟著陪葬了。 ;全球B型肝炎患者分布情形;全球B型肝炎患者分布情形;HBsAg Prevalence;HBsAg Prevalence;HBsAg Prevalence;亞洲地區慢性B型肝炎感染情況;Age at Infection;西藥與B型肝炎治療;現況;Intron A;Interferon Signal Transduction;Epivir-HBV;;Adefovir Dipivoxil;;台灣現況;西藥市場;B型肝炎治療;中藥與B型肝炎治療;中醫對肝的定義?;爆肝 v.s 保肝;中醫肝炎治療;中醫肝炎治療;對症下藥(B型肝炎);真珠草清除B肝病毒具潛力;作用機制;中西醫比較;檢驗試劑與疫苗;檢驗試劑相關簡介;;衛生署規定;;;;;HBV的檢驗方式;其他檢測系統;檢驗試劑市場;肝炎檢驗試劑;B型肝炎疫苗;發展;新生兒B型肝炎疫苗接種;保護效力 (protective efficacy);疫苗市場;B型肝炎疫苗;TiQeNbJ8G5D1A-x*t$qYnVkSgPdMaI7F3C0z)vs!pXmUiRfOcK9H6E2B+y(u%rZoWlThQeNbJ8G4D1A-w*t$qYnVjSgPdLaI7F3C0y)vs#pXmUiRfNcK9H5E2B+x(u$rZoWkThQeMbJ7G4D1z-w*t!qYnVjSgOdLaI6F3C0y)v%s#pXlUiRfNcK8H5E2A+x(u$rZnWkThPeMbJ7G4C1z-wt!qYmVjRgOdL9I6F3B0y(v%s#oXlUiQfNbK8H5D2A+x*u$rZnWkShPeMaJ7G4C1z)wt!pYmVjRgOcL9I6E3B0y(v%r#oXlTiQfNbK8G5D2A-x*u$qZnVkShPdMaJ7F4C0z)ws!pYmUjRgOcL9H6E3B+y(v%r#oWlTiQeNbK8G5D1A-x*t$qZnVkSgPdMaI7F4C0z)vs!pXmUjRfOcK9H6E2B+y(u%rZoWlThQeNbJ8G4D1A-w*t$qYnVkSgPdLaI7F3C