不同剂量左氧氟沙星治疗耐多结核病临床疗效比较.docVIP

不同剂量左氧氟沙星治疗耐多药结核病临床疗效比较 　　[摘要] 目的 比较不同剂量左氧氟沙星治疗耐多药结核病的临床疗效。方法 方便选取该院2013年7月―2014年10月收治的80例耐多药结核病患者进行研究，随机分为实验组和对照组。对照组40例，采用左氧氟沙星剂量为400 mg/d；实验组40例，采用左氧氟沙星剂量为600 mg/d。比较两组患者痰菌阴转率、治疗效果与不良反应发生率。 结果 治疗后对照组患者不同时期的痰菌阴转率低于实验组，且治疗有效率80.0%低于实验组92.5%，差异有统计学意义（P0.05）。结论 给予耐多药肺结核患者左氧氟沙星治疗效果明显，推荐剂量为600 mg/d，利于病情控制。 中国论文网 /6/viewhtm　　[关键词] 不同剂量；左氧氟沙星；耐多药结核病 　　[中图分类号] R521 [文献标识码] A [文章编号] 1674-0742（2016）07（b）-0117-02 　　Comparison of Clinical Efficacy of Different Doses of Levofloxacin in the Treatment of Multi drug Resistant Tuberculosis 　　ZHANG Zi-sheng 　　Fujian Provincial Center for Disease Control and prevention second out patient department， Fuzhou ，Fujian Province， 350007 China 　　[Abstract] Objective To compare different doses of levofloxacin in the treatment of multi drug resistant tuberculosis clinical curative effect. Methods Convenient selection of multi drug resistant tuberculosis patients in our hospital from July 2013 to October 2014. 80 cases were randomly divided into experimental group and control group. The control group of 40 cases， the use of levofloxacin dosage is 400 mg/d； 40 cases in the experimental group， the levofloxacin dose was 600 mg/d. compared two groups of patients with sputum negative conversion rate， and the incidence of adverse reactions in the treatment group. Results Sputum in patients with different stages of negative conversion rate is lower than the experimental control group after treatment， and the total effective rate was 80% lower than the experimental group 92.5%， the difference was significant （P 0.05）. Conclusion The effect of levofloxacin in patients with multi drug resistant pulmonary tuberculosis treatment significantly， the recommended dose is 600mg/d， conducive to disease control. 　　[Key words] Different doses； Levofloxacin； Multi drug resistant tuberculosis 　　呼吸道感染是引发结核病的主要病因，病发率与致死率高，严重危害患者的身心健康与生命安全[1]。结核病对多种药物具有耐药性，不利于患者治疗。因此选取正确的抗结核药物、制定适当的化疗方案是治疗耐多药结核病的关键。有研究显示[2]，氟喹诺酮类药物对引发耐多药结核病的分枝杆菌具有较好的杀菌活性。左氧氟沙星作为一种典型的氟喹诺酮类