OSAHS合并T2DM患者血清TNF-a水平变化及其相关因素分析.docVIP

OSAHS合并T2DM患者血清TNF-a水平变化及其相关因素分析 　　摘要：目的探讨阻塞性睡眠呼吸暂停低通气综合症（OSAHS）及其合并2型糖尿病（T2DM）患者肿瘤坏死因子-a（TNF-a）的血清水平变化及其相关性因素分析。方法将研究对象分为正常组16例，OSAHS组29例，OSAHS合并T2DM组8例，采用双抗体夹心酶联免疫吸附法检测并比较三组患者血清TNF-a的水平。结果OSAHS合并T2DM组血清TNF-a水平高于单纯OSAHS组和健康对照组（P＜0.05）；单纯OSAHS组血清TNF-a水平高于健康对照组（P＜0.05）。结论 OSAHS可以引起糖代谢异常，从而诱发和（或）促进T2DM的发生、发展。同时T2DM也可增加OSAHS的发生，且可加重OSAHS的症状。 　　关键词：阻塞性睡眠呼吸暂停低通气综合症（OSAHS）；2型糖尿病（T2DM）；肿瘤坏死因子-a（TNF-a） 　　Obstructive Sleep Apnea Hypoventilation Syndrome with Type 2 Diabetes Mellitus in Patients with Serum TNF - a Level Changes and Correlation Analysis 　　ZHAO Zi-hong 　　(Department of Internal Medicine,Laixi Municipal Hospital,Laixi 266600,Shandong,China) 　　Abstract：ObjectiveTo explore the changes of tumour necrosis factor-alpha (TNF-a) of serum levels in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and OSAHS associated type 2 diabetes mellitus(T2DM) and their significance.Methods All observed subjects were divided into 3 group:16 cases of normal subjects,29 cases of simple OSAHS patients,8 cases of OSAHS associated T2DM patients,TNF-a concentrations of serum were measured by the enzyme-linked immuno sorbent assay kit(ELISA) and were compared among 3 groups.Results TNF-a levels of serum were higher in OSAHS associated with T2DM patients than those in simple OSAHS patients and control subjects(P＜0.05) and those were higher in simple OSAHS patients than those in control subjects (P＜0.05).ConclusionOSAHS patients are easy to cause glycomtabolism disorder,thereby exoke and (or) to promote the development of T2DM.Meanwhile,T2DM can addable the probability of OSAHS and aqqratate the wymptom of OSAHS. 　　Key words：Obstructive sleep apnea-hypopnea syndrome(OSAHS); OSAHS associated type 2 diabetes mellitas (T2DM); TNF-a阻塞性睡眠呼吸暂停低通气综合症（obstructive sleep apnea-hypopnea syndrome，OSAHS）是一种最常见的以睡眠呼吸障碍性疾病，临床表现在睡眠中出现打鼾及较长时间的反复性有呼吸暂停或被憋醒，夜间出现低氧血症、高碳酸血症和被打乱的睡眠结构紊乱等表现，导致头痛、嗜睡、疲劳、记忆力下降等，合并心脑血管并发症及至多系统受损[1]。在临床上常常与2型糖尿病（T2DM）共存的。近年来研究发现，OSAHS患者中糖尿病的患病率40%，而糖尿病患者中OSAHS患病率23%[2-3]