牙龈炎、牙周炎患者龈沟液和血清中白细胞介素的含量及其与牙周指数的相关性.docVIP

PAGE1 / NUMPAGES2 牙龈炎、牙周炎患者龈沟液和血清中白细胞介素8的含量及其与牙周指数的相关性nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; 作者：黄亚莉，陈曦，张苏丽，刘利锋，赵亮nbsp; 【摘要】nbsp; 目的 研究白细胞介素8(IL8)在牙周炎和牙龈炎中的来源，以及与临床指数间的相关性。方法 采用双抗夹心酶联免疫吸附法(ELISA )测定成人牙周炎、牙龈炎患者及正常对照者龈沟液(GCF)及血清中的IL8含量。结果 ①牙周炎患者GCF中IL8含量明显高于对照组GCF中的含量(Plt;0.001)及牙周炎患者血清中的含量(Plt;0.001)，与牙龈炎患者GCF中的含量无显著性差异(Pgt;0.05)；②牙龈炎患者GCF中IL8含量高于对照组GCF中的含量(Plt;0.05) ；③牙周炎患者GCF中IL8含量与探诊出血指数(BI)、牙周袋深度(PD)、附着丧失(AL)呈正相关关系(Plt;0.05)。结论 IL8主要来源于牙龈组织局部；在牙周炎的发生过程中IL8并没有参与骨吸收；牙周炎患者GCF中IL8水平与PD、BI、AL呈正相关关系。 【关键词】nbsp; 牙周炎；牙龈炎；龈沟液；血清；白细胞介素8 　　Measurements of IL8 in gingival crevicular fluid and　in serum from patients with gingivitis and periodontitis　and study of its correlation with clinical indexes 　　ABSTRACT: Objectivenbsp; To study the source of interleukin8 (IL8) in gingivitis and periodontitis and its correlation with clinical indexes. Methodsnbsp; IL8 contents in gingival crevicular fluid (GCF) were measured in periodontitis, gingivitis and healthy controls with sandwich enzymelinked irnmunosorbent assay (ELISA). In addition, IL8 contents in serum were studied in periodontitis and healthy controls at the same time. Resultsnbsp; ① IL8 level in GCF was markedly higher in periodontitis than in healthy controls (Plt;0.001) and than in serum of periodontitis (Plt;0.001). IL8 level in GCF was not significantly different between adult periodontitis and gingivitis (Pgt;0.05). ② There was a significant difference of IL8 in GCF between adult gingivitis and healthy controls (Plt;0.05). ③ IL8 level in GCF of the patients with periodontitis had a positive correlation with BI, PD and AL(Plt;0.05). Conclusionnbsp; IL8 in GCF is derived from local gingival tissues. IL8 is not involved in bone absorption in the process of adult periodontitis. IL8 level in GCF of patients with periodontitis has a positive correlation with BI, PD and AL. 　　KEY WORDS: periodontitis; gingivitis; gingival crevicular fluid; serum; interleukin8 　　在牙周炎