ch1gangan生化课间绪论.pptxVIP

Introduction What is the Biochemistry ?History and development?What is the Biochemistry discussion?Biochemistry and Chinese medicine?BiochemistryDefinition: The chemistry of lifeThe science concerned with the chemical basis of lifeThe science concerned with the various molecules that occur in living cells and organisms and with their chemical reactionAnything more than a superficial comprehension of life – in all its diverse manifestation - demands a knowledge of biochemistryBiochemistry Aim: to describe and explain, in molecular terms, all chemical processes of living cellsStructure-functionMetabolism and RegulationHow life began？The scope is as wide as life itselfBiochemistry Significance: be essential to all life sciences as the common knowledge Genetics; Cell biology; Molecular biologyPhysiology and ImmunologyPharmacology and PharmacyToxicology; Pathology; MicrobiologyZoology and BotanyBiochemistry Medical students who acquire a sound knowledge of biochemistry will be in a strong position to deal with two central concerns of the health sciences: (1) the understanding and maintenance ofhealth (2) the understanding and effective treatment of diseaseHistory and development?1903 Neuberg 首先提出生物化学概念发展：静态—动态—机能生物化学1953 Watson and Crick DNA双螺旋结构 （分子生物学）1972 Berg gene engineering1976 Kan 胎前检验 beta-地贫1977 Shine 克隆了人生长激素抑制基因1982 Cech发现四膜虫rRNA可自我剪切 （Ribozyme）1986 Mullis PCR技术1990 基因治疗进入临床（ADA）2001 HGP完成---后基因组学时代---蛋白质组学—生物信息学1903 年 Carl Neuberg首次提出“生物化学” A pioneer biochemist, Carl Neuberg (1877-1956) spent over thirty years of his productive career as a professor at the University of Berlin (1903-1937) and as Director of the Kaiser Wilhelm Institutes of Biochemistry and Experimental Therapy. His varied research interests resulted in important contributions to the understanding of fermentation processes, solubility and transport phenomena in cells, the chemistry of carbohydrates, sugars, enzymes, and amino acids, and photochemistry. Neuberg was forced out of his po