冠心病治疗冲突和策略.pptVIP

* * * 无事件发生率 尼可地尔 安慰剂 风险降低14% P=0.027 随访时间(年) HR：0.86 95%CI：0.75～0.98 尼可地尔显著降低所有心血管事件发生率 14% 1. IONA Study Group. Lancet. 2002 Apr 13;359(9314):1269-75. 所有心血管事件包括：心血管死亡、非致死性心梗、非致死性卒中、 因短暂性脑缺血入院、因心源性胸痛意外入院 * 2013年ESC SCAD指南 7.1.3.3.5 Nicorandil. Nicorandil is a nitrate derivative of nicotinamide that can be used for the prevention and long-term treatment of angina,177 and may be added after b-blockers and CCBs. It is EMA but not FDA approved. Nicorandil dilates epicardial coronary arteries and stimulates ATP-sensitive potassium channels (KATP) in vascular smooth muscle. In the prospective Impac