慢性间歇性缺氧对大鼠认知障碍及rage lrp1在血脑屏障表达的影响-effects of chronic intermittent hypoxia on cognitive impairment and rage lr p1 expression in blood-brain barrier in rats.docxVIP

PAGE PAGE 6 rats(P﹥0.05). Spatial Exploration:to compare with UC group and AUC group ,the frist time passing hide plateform prolonged significantly in CIH rats（P0.05）and the times acrossing crossing plateform of CIH rats were declined（P0.05）. （2）①Comparing with the positive rate of RAGE protein in UC and AUC rats′ endothelial cells and microglia of the BBB,that in CIH was 70％and was significantly higher than their positive rate(26.7%；33.3%) in UC rats′ and AUC rats′, there were the significant differences （P0.05）. The expression of RAGE（MOD value） has significantly increased( P0.05) ②The positive rate of LRP1 protein in UC rats′endothelial cells and microglia of the BBB was 33.33 ％, was significantly lower than its positive rate(73.33%) in UC rats′ and AUC rats′,but the LRP1 has decreased in blood-brain barrier. ( 3 )The corrlation between expression of RAGE and Morris water maze test learning scores： ①The expression of RAGE and escape latency in rats was positively correlated( r=0. 658， P0.05). ②The expression of RAGE and the frist time passing hide plateform was positively correlated （r=0. 328，p0.05）.③There was negative correlation between the expression of RAGE and the times acrossing crossing plateform（rs=-0.488，p0.05）. ( 4 ) The corrlation between expression of LRP1 and Morris water maze test learning scores： ①The expression of LRP1 and escape latency in rats was negatively correlated( r=- 0. 483， P0.05). ②The expression of LRP1 and the frist time passing hide plateform was negatively correlated （r=- 0. 484，p0.05）.③There was positive correlation between the expression of LRP1 and the times acrossing crossing plateform（rs=0.643，p0.05）. Conclusion 1、After the treatment of chronic intermittent hypoxia,the rats′ Morris water maze test learning scores were bad, suggesting that Chronic intermittent hypoxia could lead to cognitive impairment of the rats. 2、The expression of RAGE protein in endothelial cells and microglia of the BBB of the rat treated by chronic int