模拟co,2气腹对胃癌mkn-45细胞整合素介导的fak信号通路的影响-effects of simulated co, 2 pneumoperitoneum on fak signal pathway mediated by integrin in gastric cancer mkn - 45 cells.docxVIP
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模拟co,2气腹对胃癌mkn-45细胞整合素介导的fak信号通路的影响-effects of simulated co, 2 pneumoperitoneum on fak signal pathway mediated by integrin in gastric cancer mkn - 45 cells
第三军医大学硕士学位论文
第三军医大学硕士学位论文
4
4
hours,4 hours were significantly different from the control(p0.01),while the group of cultured in normal environment for 1 hour after being treated for 4 hours was not significantly
different from the control(p0.05);
4. The Integrinβ1 expressions of all groups were not significantly different from each other.
Conclusion:
In vitro, CO2 pneumoperitoneum can not promote the FAK expression of Gastric Cancer MKN-45 Cell in 4 hours;
5mmHg and 10mmHg CO2 pneumoperitoneum can not effect the FAK’s activity of the Integrin/FAK signal pathway ,but 15mmHg CO2 pneumoperitoneum can activate FAK through increasing FAK Tyr397 phosphorylation, and the activity of FAK is promoted with the time of being treated.Once departs from the CO2 pneumoperitoneum, the activity decreases to the levels that before treated rapidly.
CO2 pneumoperitoneum can not promote the Integrinβ1 expression of Gastric Cancer MKN-45 Cell in 4 hours,indicates that CO2 pneumoperitoneum is not through promoting the expressing of Integrinβ1 to activate the FAK of Gastric Cancer MKN-45 Cell.
The CO2 pneumoperitoneum pressure used in clinical practice may have no influence on gastric cancer cell proliferation and metastasis through Integrin/FAK signal pathway.
KeyWords: CO2 Pneumoperitoneum; Gastric cancer cells; FAK; Phospho-FAK; Integrinβ1
PAGE
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英文缩写
英文缩写一览表
英文全称
中文全称
CO2
d
carbon dioxide
day
二氧化碳 天
FAK
Focal Adhesion Kinase
粘着斑激酶
ddH2O
double distilled H2O
双蒸水
DMSO
dimethylsulfoxide
二甲基亚砜
phospho-FAK
Phosphorylated Focal Adhesion Kinase
磷酸化粘着斑激酶
ECM
extracellular matrix
细胞外基质
EDTA
ethylenediaminetetraacetic acid
乙二胺四乙酸
FCM
flowcytometry
流式细胞术
FCS
fetal calf serum
胎牛血清
FITC
fluorescein isothiocyanate
异硫氰酸荧光素
h
hour
小时
kDa
kilodalton
千道尔顿
min
minute
分钟
ml
milliliter
毫升
mmHg
millimetre of mercury
毫米汞柱
MTT
methyl thiazolyl tetrazolium
四甲基偶氮唑盐
OD
opitcal density
光密度值
PBS
phosphate buffered solution
磷酸盐缓冲液
rpm
round per minute
每分钟转速
s
second
秒
Tris
trihydroxymethylaminom
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