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mycobacteria home to established granulomas超感染分枝杆菌肉芽肿回家了ppt课件
Superinfecting mycobacteria home to established granulomas;Background;Background;Electron micrograph of Mycobacterium tuberculosis;↑
Caseous necrosis
→;Colonies of Mycobacterium tuberculosis on Lowenstein-Jensen medium. CDC ;Introduction;Introduction;Results;Do frogs chronically infected w/ M. marinum have partial immunity to superinfections?; 2) Mycobacteria transport to established granulomas via host cells;Arrow: epithelioid macrophages;Infect frogs w/ red fluorescent M. marinum for 8 wks to establish chronic granulomatous infection
Superinfect frogs w/ green fluorescent bacteria
Examine tissue at 10 wks and 20 wks after superinfection;The superinfecting strain also established its own granulomas.;Do the mixed granulomas represent trafficking of superinfecting bacteria into established granulomas, or remodeling of adjacent granulomas first established separately by the 2 strains?;a) Infected w/ red, s.i. 7 wks w/ green;Are superinfecting mycobacteria gaining passage into established granulomas w/in host cells?;Result: At 3 days post superinfection, dually red/green fluorescent bacteria were within preexisting granulomas…; 3) Mycobacterium-infected monocytes show enhanced trafficking;Is the accumulation of mycobacterium-infected cells in granulomas enhanced compared with that of uninfected phagocytic cells?;Results: Similar proportions of bacteria and beads reached the liver;Is the greater number of superinfecting bacteria compared with the beads in pre-established lesions due to preferential replication, rather than increased trafficking?; 4) Trafficking is pathogen specific;Is the trafficking of mycobacterium-infected cells into granulomas pathogen specific?;S. arizonae-infected cells located in many small aggregates @ 3 days and in fewer larger aggregates @ 7 days
;A few S. arizonae were present in preexisting M. marinum granulomas at 3 days;Is the trafficking pathogen specific in competition?;The close juxtaposition of the large Salmonella granulomas and
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