妊娠糖尿病患者胰岛素抵抗及胰岛细胞功能与空腹血清fgf21 nesfatin-1的相关性研究-correlation between insulin resistance, islet cell function and fasting serum fgf 21 nesfatin - 1 in patients with gestational diabetes mellitus.docxVIP

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妊娠糖尿病患者胰岛素抵抗及胰岛细胞功能与空腹血清fgf21 nesfatin-1的相关性研究-correlation between insulin resistance, islet cell function and fasting serum fgf 21 nesfatin - 1 in patients with gestational diabetes mellitus.docx

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妊娠糖尿病患者胰岛素抵抗及胰岛细胞功能与空腹血清fgf21 nesfatin-1的相关性研究-correlation between insulin resistance, islet cell function and fasting serum fgf 21 nesfatin - 1 in patients with gestational diabetes mellitus

目录中英文缩略词表····································································1中文摘要····································································3英文摘要········································································5正文·······································································81前言··························································82材料和方法·······························································103结果···········································································144讨论···········································································245结论·······································································30参考文献··········································································31附录·····························································35致谢·······················································37综述及参考文献·····························································39中英文缩略词表英文缩写英文全称中文全称GDMGestationaldiabetesmellitus妊娠糖尿病OGTToralglucosetolerancetest口服葡萄糖耐量试验BMIbodymassindex体质指数IRInsulinresistance胰岛素抵抗FPGFastingplasmaglucose空腹血糖FINSFastingInsulin空腹胰岛素HOMA-IRHomeostasismodelassessmentinsulinresistanceindexHOMA-βHomeostasismodelassessmentβcellinsulinsecretionindex稳态模型胰岛素抵抗指数胰岛β细胞功能指数INSAUC/PGAUCareaunderinsulin/areaunderglucose胰岛素曲线下面积/血糖曲线下面积△I30/△G30earlyinsulinsecretionindex早期胰岛素分泌功能指数FGF21fibroblastgrowthfactor21成纤维细胞生长因子21NUCB2Nucleobinding2核组蛋白2ELISAenzyme-linkedimmunosorbentassay酶联免疫吸附法ADAAmericanDiabetesAssociation美国糖尿病协会RBP4Retinol-bindingprotein4重组人视黄醇结合蛋白4妊娠糖尿病患者胰岛素抵抗及胰岛细胞功能与空腹血清FGF21、Nesfatin-1的相关性研究中文摘要目的1.观察妊娠24-28周孕妇口服葡萄糖耐量试验（OGTT）后不同空腹血糖水平妊娠糖尿病（GDM）患者胰岛素抵抗及胰岛细胞功能之间的差异及相关性分析；2.检测妊娠糖尿病患者空腹血清FGF21和Nesfatin-1水平变化，分析其与胰岛素抵抗及胰岛素细胞功能之间的关系。方法1.收集2012年5月至2013年3月至本院行口服葡萄糖耐量试验(OGTT)的妊娠24~28周孕妇90例，根据2012年美国糖尿病学会（ADA）制定的妊娠糖尿病诊断标准和OGTT结果分为妊娠糖尿病（GDM）组45例和糖耐量正常组（NGT）45例，并以空腹血糖（FPG）7.0mmol/L为切割点，将GDM组分为GDM1组（5.1mmol/L≤FPG＜7.0mmol/L）27例和GDM2组（FPG≥7.0mmol/L）18例，其年龄、孕前体重指数及孕期增加体重指数相匹配。2.采用问卷调查方式记录受试者姓名、年龄、家族史、