噬血细胞综合症HLH发病机制和诊治进展ppt课件.pptVIP

1093 serum ferritin measurement ?500?g/L at Texas Children’s Hospital (2003–2005)from 330 patients. Median admission ferritin: 5992 ?g/L (757-63919 ?g/L) Median maximal ferritin: 15830?g/L (994-189721 ?g/L) Specificity of 96% and sensitivity of 90% with ferritin?10000?g/L as cut-off point Serum GDF15 is remarkably increased in ? and ? thalassemias, and is positively correlated to sTfR, ferritin and EPO, and negatively correlated to Hb concentration Tanno T, et al. Nat Med. 2007;13(9):1096-1011. Serum GDF15 in normal control: 450?50 pg/ml Serum GDF15 in thal trait: 820?100pg/ml Serum GDF15