The β_Adrenergic Receptor System.pptVIP

主讲：滕秋霞 The adrenergic receptors are a class of metabotropic G protein-coupled receptors that are targets of the catecholamines, especially noradrenaline and adrenaline. α receptors have the subtypes α1 (a Gq coupled receptor) and α2 (a Gi coupled receptor). Phenylephrine is a selective agonist of the α receptor. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins (although β2 also couples to Gi). Isoprenaline is a selective agonist of the β receptor. the β-adrenergic receptors exist in muscle, liver, and adipose tissue. vasodilation vasoconstriction Adrenaline reacts with both α- and β-adrenoreceptors, causing vasoconstriction and vasodilation. The mechanism of adrenergic receptors. Adrenaline or noradrenaline are receptor ligands to either α1, α2 or β-adrenergic receptors. β receptors couple to Gs, and increases intracellular cAMP activity, resulting in e.g. heart muscle contraction, smooth muscle relaxation and glycogenolysis. ATP cAMP The β-adrenergic receptor is an integral protein with seven seven transmembrane helices. Epinephrine binds to its specific Replace of the GDP bound to Gs by GTP, activating Gs Gs (α subunit) moves to adenylyl cyclase and activates it Good morning .everyone! I’m very excited to be here with you. our group’s topic is about the b adrenergic receptors system. * So what is the b adrenergic receptors system? Look at this picture. This is the b adrenergic receptor. It is coupled to the Gs protein,which activate adenlyl cyclase,catelysing the formation of camp. The assembly of the signaling complex proviedes a mechanism that ensures specific and rapid signaling. First ,let me introduce the adrenergic receptors to you. The adrenergic[,?dr?n?d??k] receptors are a class of metabotropic[met?b?tr?pik] G protein-coupled receptors .They are targets of the catecholamines[k?tik?ul?mi:n]s, especially noradrenaline[n?:r?dren?lin] and adrenaline[?dren?lin] * There are two main gr