石墨烯纳米杂化材料制备及其在生物成像和光热治疗中应用-preparation of graphene nano-hybrid material and its application in biological imaging and photothermal treatment.docxVIP

attenuationpropertyincellularleveloreveninthetumor-bearingmice,whichindicatesthattheobtainedmaterialisapromisingmulti-modalbiologicalimagingcontrastagent.Finally,wecarriedouttheinvivocancerphotothermaltherapybyintravenousinjectionofGO/BaGdF5/PEGandthefollowing808-nmlaserirradiationandobtainedidealphotothermaltumorablationeffect.GO/BaGdF5/PEGnanomaterialsconbineMR,CTimagingandphotothermaltherapyfunctionsintoonesystem,andtheyshowpromisingapplicationpotentialinbiomedicalfields.ThethirdchapteristheresearchabouttheCTimagingandcancerphotothermaltherapyapplicationsofGO/Bi2Se3/PVPnanomaterials.IdealCTimagingeffectwasobtainedafterintratumoralinjectionofthematerial,whichrevealsthatGO/Bi2Se3/PVPmaterialisapromisingCTimagingcontrastagent.Atthesametime,theinvivocancerphotothermaltherapyexperimentswerecarriedoutbydirectlyintratumoralinjectionofthematerial,andidealcancerphotothermalablationeffectwereobtained.Finally,weresearchedtheinvivotoxicityofGO/Bi2Se3/PVPmaterialtothetumor-bearingmice.TheGO/Bi2Se3/PVPmaterialshowlowtoxicityafterintravenousinjectionintothemice.Therefore,GO/Bi2Se3/PVPmaterialcanbeusedforbioimagingcontrastagentandcancerphotothermaltherapy.Thefourthchaptersummarizestheimportantexperimentaldataandresultsobtainedinthiswork.Finally,weshowtheoutlooksaboutthefurtherapplicationsofGObasednanomaterialsinthefuture.Keywords:grapheneoxide,BaGdF5,bismuthselenide,magneticresonanceimaging,CTimaging,photothermaltherapyIV目录摘要................................................................................................................................IAbstract........................................................................................................................III目录...............................................................................................................................V第一章绪论..................................................................................................................11.1氧化石墨烯的简介...........................................