心衰中的分子医学系列（英文）ppt课件.pptVIP

Series on Molecular Medicine in Heart FailureIon Channel Remodeling in Heart Failure;;Ion Channel Remodeling and Heart Failure;Michael, G. et al. Cardiovasc Res 2009 81:491-499; doi:10.1093/cvr/cvn266;Na-Ch;Copyright restrictions may apply.;Cardiac Sodium Channel;III;Not1;-100 mV;Prolonged QTc High incidence of cardiac arrhythmias and sudden death Late INa current;;Seizure in TG-LQT3 Mice;Optical MappingRepeated multiple ventricular extrasystoles ;Optical Mapping Initiation of spontaneous VT/VF episode in TGM ;Optical Mapping Reentry mechanism is responsible for maintaining VT/VF episode ;Na+;Identification of Dilated Cardiomyopathy and Heart Failure in TG-LQT3 Mice;TG-LQT3;Systole;Systole;Systole;TG-LQT3;LQTS and DCM/Heart Failure in Humans;LQTS and Heart Failure in Humans;Potential Causes of Dilated Cardiomyopathy and Heart Failure in TG-LQT3 Mice;a;P=0.040907;Masson’s Trichrome Staining for Myocardial Fibrosis;Potential Causes of Cardiomyopathy Apoptosis in TG-LQT3 Mice;Na-Ch;Na-Ch N1325S;Intracellular Sodium Overload in TG-LQT3 Cardiomyocytes;10 ms;Sodium Channel Blocker TTX Attenuates Intracellular Calcium Abnormalities in TG-LQT3 Cardiomyocytes;0 Extracellular Calcium Attenuates Intracellular Calcium Abnormalities in TG-LQT3 Cardiomyocytes;No NCX Current in TG-LQT3 Cardiomyocytes;Conclusion