细胞信号转导ii课件.pptVIP

Signal Transduction;Diversity, Receptors, GTPase switch proteins, protein kinases, adaptor proteins, protein phosphatases ;The major signaling pathways activated by GPCRs and RTKs;3.2 Cytokine receptors pathway;Erythropoietin and red blood cells ;Janus, Roman two faced God of Gate;Janus Kinase/STAT signaling pathway;The JAK - STAT signaling pathway;Erythropoietin (a cytokine) may activate several pathways;Expression of erythrocytes in mutant mice;;... the one thing that I think is extremely important, is that anyone can do it, if given a chance, if given the opportunity. ;From http://www.N.;;Question;3. Signaling through Enzyme-linked receptors;3.3 TGF? receptors pathway;Smads family;TGF? binds type III / type II receptor;TGF? signaling pathway;TGF? pathway in physiology and pathology;TGF? signaling in health and disease ;Overview of Enzyme-linked receptors;4. Signaling that involved in proteolysis;4.1 NF-?B (nuclear factor ?B ) pathway;NF-kB signaling pathway;TNF-alpha inhibitors available by prescription ;Varfolomeev et al., IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis. Cell 131, 669-681, 16 November 2007. Vince et al., IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis. Cell 131, 682-693, 16 November 2007. ;4. Signaling that involved in proteolysis;Cell recognition--communication by plasma membrane-bound proteins;4.2 Notch/Delta signaling pathway;Notch/Delta signaling pathway;Artist charts his slide into dementia, Galerie Beckel Odille Boicos, Paris.Six self-portraits by artist William Utermohlen chronicle his experience with Alzheimers disease. Utermohlen was diagnosed at the age of 60. The first in this series (top left) was painted in 1996, just prior to diagnosis.  By David Derbyshire (29/06/2001) ? Copyright of Telegraph Group Limited 2005;Alzheimers disease;Proteolytic cleavage of APP, a neuronal plasma protein;4. Signaling that involved in proteolysis;4.3 Hedgehog (Hh) pathway;Hedge