拟除虫菊酯类杀虫剂ppt课件_2.pptVIP

二、菊酯类杀虫剂的作用机理 钠离子通道 二、菊酯类杀虫剂的作用机理 钠离子通道 二、菊酯类杀虫剂的作用机理 In the case of the voltage-gated sodium channel, the gate is controlled by a voltage sensor, which responds to the level of the membrane potential. 二、菊酯类杀虫剂的作用机理 /conj/membrane/nachan.htm 二、菊酯类杀虫剂的作用机理 The interaction of pyrethroids with the sodium channel has the effect of slowing both the activation and inactivation properties of the sodium channel. 二、菊酯类杀虫剂的作用机理 In the phase of the action potential even the low proportion of modified channels can generate enough extra current to delay inactivation. This slower rate of inactivation of pyrethroid-modified channels generates a prolonged depolarizing “tail” current. 二、菊酯类杀虫剂的作用机理 This “tail” can trigger a second action potential if the current is large enough and lasts for more than 0.5 ms. 二、菊酯类杀虫剂的作用机理 Another significant feature is that, after modification by pyrethroids, sodium channels retain many of their normal function. This means that after exposure to moderate doses of pyrethroids cells can continue to function, but in a new and relatively stable state of abnormal hyper-excitability. 二、菊酯类杀虫剂的作用机理 In insects this state corresponds to the incapacitating(使无能力) but sublethal effect known as “knock down”. 二、菊酯类杀虫剂的作用机理 An important characteristic of the pyrethroid-generated tail current is that the amplitude(振幅) and duration are independent. The current amplitude is dependent only on the proportion of sodium channels modified, and hence shows a sigmoid(S形的) relationship with concentration or dose. 二、菊酯类杀虫剂的作用机理 The current duration is dependent only on the pyrethroid structure. Individual pyrethroids thus generate a characteristic time constant for prolongation of the sodium channel tail current that is virtually(差不多) independent of dose. 二、菊酯类杀虫剂的作用机理 There is a continuous distribution of time constants(恒定的) across the range of pyrethroid structures, with type I pyrethroids producing the shorter time constants, and type II pyret