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Endometrial Cancer;Endometriod cancer---Contents;WHO Cancer Report;Histologic Types; Endometrial Cancer:Type I/II;Endometrial Cancer: Risk Factors;Endometrium Carcinoma2009 Classification;Stage I (73%);Endometrial Cancer Prognosis:;Aggressive Histologic Subtypes (Clear-cell, Serous) Increasing age (over 65) Vascular invasion Aneuploidy Altered oncogene/tumor suppressor gene expression ( “molecular staging” concept- p53, PTEN, microsatellite instability, MDR-1, HER2/neu, ER/PR, Ki 67, PCNA, CD 31,EGF-R, MMR genes) Race? ;Molecular Genetics;Molecular Genetics;Genetic Syndromes: HNPCCHereditary Non-Polyposis Colon Cancer;Diagnosis of disease: Patient Awareness*;Uterine Cancer:Diagnosis/Screening;Endometrial Cancer:Transvaginal Ultrasound Screening;Endometrial Cancer:Transvaginal Ultrasound Screening;Endometrial Cancer:Transvaginal Ultrasound Screening;Normal endometrial stripe: Postmenopausal 4- 8 mm Postmenopausal on HRT 4- 10 mm U/S for Detection of any uterine pathology Sensitivity: 85-95% Specificity: 60-80% PPV 2-10% NPV 99%;Hysteroscopy – Not satisfactory for screening test;Hysteroscopy and Positive Cytology?;Hysteroscopy – Not satisfactory;Endometrial Cancer:Who Needs an Endometrial Biopsy?;Sampling of the Endometrium;Treatment for Endometrial Hyperplasia without atypia:;Treatment for Atypical Endometrial Hyperplasia:;Treatment for Atypical Endometrial Hyperplasia:;Endometroid carcinoma, Grading;CA125 Chest X-ray Mammograms Colon Evaluation Others as indicated;Uterine Cancer: Pre-op Evaluation;Uterine Cancer: Pre-op Evaluation;Uterine Cancer: Surgical Staging;Availability of frozen section to determine the extent of staging procedure. Capability of complete surgical staging Capability of tumor reduction if indicated;Endometrial Cancer: Surgical Approach;Endometrial Cancer: Surgical Approach;Endometrial Cancer: Adjuvant Therapy;Endometrial Cancer: Recurrence;Endometrial Cancer: Site of RecurrenceIn Radiated Patients;Endometrial Cancer: Follow-Up