唯支持细胞综合征实验室指标与临床诊断的相关性分析-correlation analysis between laboratory indicators and clinical diagnosis of sertoli cell syndrome only.docxVIP

ofSCOS.ResultsTherewasnodifferenceinsemenvolumeandsemeliquefactiontime.Spermdensity,totalspermcount,spermviabilityandpercentageofspermwithdifferentmotility(alevels,a+blevels)allwere0,majorityofpatientsreceivedonlyaroutineexaminationofsemen.ThesexhormonelevelsshowedthatFSHwassignificantlyhigherthannormal.Seminalplasmabiochemicalexaminationshowedthatfructoseandα-glucosidasewerenormal;therewasnoabnormalkaryotypeinchromosomeexamination.OnlyonecasesofpatientswasfoundwithAZFdeletion,mainlyinAZFdregionandAZFcregiondeletion,accuratelyfortheSTSlocationsY152,sY239,sY242,sY254,sY255commondeletion;socringsystemfotesticularbiopsies(Johnsenscore)promptedfocalSCOSpatientswithahigherproportionofspermatogenesisarrestatspermatocytestage,whoseJohnsenscoremainlyatfour.JohnsenscoreandFSH,FSH/LHvaluesshowedanegativecorrelation.ConclusionsInordertofurtherlystandardizetheprogressofdiagnosisofSCOS:Threeormoresemenexaminationsshowedazoospermia,highFSHhormonelevel,highFSH/LHlevel,bilateraltesticularbiopsyshowedspermatogeniccellsweresignificantlyreducedorabsent,leavingonlysterolicells.AllmentionedabovecanbeusedasthediagnosticreferenceofSCOS;MorepointofbilateraltesticularbiopsywasaneedforthediagnosisofcompletiveSCOS.ChromosomalkaryotypeandseminalplasmabiochemistrycanberecommendedastheexclusionchecksofSCOS.Keywordssertoli-cell-onlysyndrome;clinicaldiagnosis;laboratoryindexes中英文缩写对照表SCOSsertoli-cell-onlysyndrome唯支持细胞综合征CASAcomputerAssistedSemenAnalysis计算机辅助精液分析STSsequence-taggedsite序列标签位点AZFazoospermiaFactor无精子因子FSHfolliclestimulatinghormone卵泡刺激素LHluteinizinghormone黄体生成素WHOWorldHealthOrganization世界卫生组织ISCIintracytoplasmicsperminjection卵子胞浆内单精子注射GnRHgonadotropin-releasinghormone促性腺激素释放激素学位论文原创性声明本论文是我个人在导师指导下进行的工作研究及取得的研究成果。论文中除了特别加以标注和致谢的地方外，不包含其他人或其它机构已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在论文中以明确方式标明。本人完全意识到本声明的法律责任由本人承担。作者签名：日期：年月日学位论文使用授权声明本人授权汕头大学保存本学位论文的电子和纸质文档，允许论文被查阅和借阅；学校可将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或其它复制手段保存和汇编论文；学校可以向国家有关部门或机构送交论文并授权其保存、借阅或上网公布本学位论文的全部或部分内容。对于保密的论文，按照保密的有关规定和程序处理。本论文属