特发性矮小患儿血清igf-1 igfbp-3水平 骨龄改变与体格发育相关性-correlation between bone age change of serum igf - 1 igf bp - 3 level and physical development in children with idiopathic short stature.docxVIP

ABSTRACTPurpose:Toinvestigatetheserumlevelsofinsulin-likegrowthfactor-1(IGF-1)、insulin-likegrowthfactorbindingprotein-3(IGFBP-3)、thechangeofboneageinchildrenwithidiopathicshortstature(ISS)andthecorrelationbetweentheseindexesandphysicaldevelopment．Methodology：80casesofchildrenaged(6~15)withISSwereselectedasISSgroup，including59boysand21girls，theaverageagewas(11.28±2.2)yearsold．50casesofnormalchildrenofthesameageandsexwerecollectedascontrolgroup．twogroupschildrenweremeasuredheightandweight,andheightstandarddeviationscore(HtSDS)、weightstandarddeviationscore(WtSDS)andbodymassindex(BMI)werecalculated．TheserumlevelofIGF-1wasdetectedbyenzyme-linkedimmunosorbentassay(ELISA)method，theserumlevelofIGFBP-3wasdetectedbychemiluminescentmethod，andIGF-1standarddeviationscore(IGF-1SDS)、IGFBP-3standarddeviationscore(IGFBP-3SDS)werecalculated．TheanteroposteriorfilmoflefthandandwristhadbeentakenbyPhilipsdigitalX-raymachine．Thedifferencesofboneageamongeachgrouphadbeencompared．Theboneagewereassessedaccordingto＂Chinachildrenboneagescore＂atlas，boneagedifference(BAD)andboneageindex(BAI)werecalculated．Theresultswereanalyzedbystatisticalmethods．Results：InISSgroupheight、weight、boneage、BMI、BAD、BAI、theserumlevelsofIGF-1andIGFBP-3werelowerthanincontrolgroup(allP0.01)．InISSgroup：IGF-1SDSandHtSDS、WtSDSwerepositivelycorrelated(r=0.552、0.436，allP0.01)；IGFBP-3SDSandHtSDS、WtSDSwerepositivelycorrelated(r=0.350、0.322，allP0.01)．InISSgroup：BADandHtSDS、WtSDSwerepositivelycorrelated(r=0.460、0.494，allP0.01)；BADandIGF-1SDS、IGFBP-3SDSwerepositivelycorrelated(r=0.599、0.444，allP0.01)．InISSgroup：BAIandHtSDS、WtSDSwerepositivelycorrelated(r=0.339、0.412，allP0.01)；BAIandIGF-1SDS、IGFBP-3SDSwerepositivelycorrelated(r=0.448、0.429，allP0.01)．Conclusions:Theboneageislaggedbehind，andtheserumlevelsofIGF-1andIGFBP-3aredecreasedinchildrenwithISS，andmorelowerthelevelsofIGF-1andIGFBP-3，morebackward.theboneage．HeightandweightwerepositivelycorrelatedwiththelevelsofIGF-1andIGFBP-3inchildrenwithISS．BADandBAIcanbeusedtoevaluatephysical